| Title: |
Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis |
| Authors: |
Lee, Mikyeong; Joehanes, Roby; McCartney, Daniel L; Kho, Minjung; Hüls, Anke; Wyss, Annah B; Liu, Chunyu; Walker, Rosie M; R Kardia, Sharon L; Wingo, Thomas S; Burkholder, Adam; Ma, Jiantao; Campbell, Archie; Wingo, Aliza P; Huan, Tianxiao; Sikdar, Sinjini; Keshawarz, Amena; Bennett, David A; Smith, Jennifer A; Evans, Kathryn L; Levy, Daniel; London, Stephanie J |
| Contributors: |
Ophthalmology and Visual Sciences |
| Source: |
Epigenomics ; 14 ; 23 ; 1479 ; 1492 ; United States ; United Kingdom ; England |
| Publication Year: |
2024 |
| Collection: |
University of Massachusetts, Medical School: eScholarship@UMMS |
| Subject Terms: |
blood; epigenetics; methylome; prescription opioids |
| Description: |
Aim: To identify differential methylation related to prescribed opioid use. Methods: This study examined whether blood DNA methylation, measured using Illumina arrays, differs by recent opioid medication use in four population-based cohorts. We meta-analyzed results (282 users; 10,560 nonusers) using inverse-variance weighting. Results: Differential methylation (false discovery rate |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Epigenomics; https://doi.org/10.2217/epi-2022-0353; http://hdl.handle.net/20.500.14038/53286 |
| DOI: |
10.2217/epi-2022-0353 |
| Availability: |
https://doi.org/10.2217/epi-2022-0353; https://hdl.handle.net/20.500.14038/53286 |
| Rights: |
Open access This work is licensed under the Creative Commons Attribution 4.0 License. To view a copy of this license, visit http://creativecomm ons.org/licenses/by/4.0/ ; Attribution 4.0 International ; http://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.6EAE1DB2 |
| Database: |
BASE |