| Title: |
Acute ischemic stroke or TIA despite DOAC treatment: the contribution of DOAC plasma levels to understand pathophysiological mechanisms |
| Authors: |
Rust, Marcus; Gözalan, Merve; Nikoubashman, Omid; Wiesmann, Martin; Imöhl, Matthias; Schulz, Jörg B.; Reich, Arno; Pinho, João |
| Publisher Information: |
Sage |
| Publication Year: |
2026 |
| Collection: |
PUB - Publications at Bielefeld University |
| Description: |
Rust M, Gözalan M, Nikoubashman O, et al. Acute ischemic stroke or TIA despite DOAC treatment: the contribution of DOAC plasma levels to understand pathophysiological mechanisms. Therapeutic Advances in Neurological Disorders . 2026;19. ; Background: Ischemic stroke or transient ischemic attack (TIA) occurs in 1.4% of patients with atrial fibrillation (AF) per year despite treatment with direct oral anticoagulants (DOACs). This group of patients is poorly studied, and possible causes for this are not fully understood.; Objectives: The aim of the study was to analyze DOAC plasma levels in patients who had ischemic stroke or TIA despite treatment with DOAC.; Design: Monocentric retrospective study.; Methods: We selected consecutive DOAC-treated patients with acute ischemic stroke or TIA, admitted during a 2-year period, with measurement of DOAC levels ⩽24h after hospital admission. Patients with and without low DOAC levels (48h before admission (72.5% vs 57.5%, p=0.004), and had higher baseline NIHSS (8 vs 4, p=0.001). Lower DOAC levels were associated with large or medium vessel occlusion (LVO/MeVO; odds ratio per 10ng/mL-increase=0.89, 95% confidence interval=0.85-0.94, p |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
1756-2856; 1756-2864 |
| Relation: |
info:eu-repo/semantics/altIdentifier/issn/1756-2856; info:eu-repo/semantics/altIdentifier/issn/1756-2864; info:eu-repo/semantics/altIdentifier/wos/001688208200001; info:eu-repo/semantics/altIdentifier/pmid/41696675 |
| Availability: |
https://pub.uni-bielefeld.de/record/3014214 |
| Rights: |
info:eu-repo/semantics/closedAccess |
| Accession Number: |
edsbas.6ECABD73 |
| Database: |
BASE |