| Title: |
Neurocysticercosis Prevalence and Characteristics in Communities of Sinda District in Zambia: A Cross-Sectional Study |
| Authors: |
Zulu, Gideon; Stelzle, Dominik; Gabriël, Sarah; Trevisan, Chiara; Van Damme, Inge; Mubanga, Chishimba; Schmidt, Veronika; Ngowi, Bernard J.; Welte, Tamara M.; Magnussen, Pascal; Ruether, Charlotte; Fleury, Agnes; Dorny, Pierre; Bottieau, Emmanuel; Phiri, Isaac K.; Mwape, Kabemba E.; Winkler, Andrea S.; the SOLID consortium |
| Source: |
http://lobid.org/resources/99370695437906441#!, 14(3):1180-1190. |
| Publication Year: |
2024 |
| Collection: |
Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| Subject Terms: |
Adolescent [MeSH]; Female [MeSH]; Neurocysticercosis/diagnosis [MeSH]; Prevalence; Adult [MeSH]; Neurocysticercosis/epidemiology [MeSH]; Humans [MeSH]; Zambia; Middle Aged [MeSH]; Cross-Sectional Studies [MeSH]; Animals [MeSH]; Point-of-care test; Cysticercosis; Tomography; X-Ray Computed [MeSH]; Neurocysticercosis; Male [MeSH]; Zambia/epidemiology [MeSH]; Taenia solium/isolation; Young Adult [MeSH]; Prevalence [MeSH]; Child [MeSH]; Research Article; Child; Preschool [MeSH] |
| Description: |
Abstract Background This study aimed at describing the epidemiology of (neuro)cysticercosis as well as its clinical and radiological characteristics in a Taenia solium endemic district of Zambia. Methods This was part of a cross-sectional community-based study conducted in Sinda district to evaluate an antibody-detecting T. solium point-of-care (TS POC) test for taeniosis and (neuro)cysticercosis. All TS POC cysticercosis positive (CC+) participants and a subset of the TS POC cysticercosis negative (CC-) received a clinical evaluation and cerebral computed tomography (CT) examination for neurocysticercosis (NCC) diagnosis and staging. Results Of the 1249 participants with a valid TS POC test result, 177 (14%) were TS POC CC+ . Cysticercosis sero-prevalence was estimated to be 20.1% (95% confidence intervals [CI] 14.6–27.0%). In total, 233 participants received a CT examination (151 TS POC CC+ , 82 TS POC CC-). Typical NCC lesions were present in 35/151 (23%) TS POC CC+ , and in 10/82 (12%) TS POC CC- participants. NCC prevalence was 13.5% (95% CI 8.4–21.1%) in the study population and 38.0% (95% CI 5.2–87.4%) among people reporting epileptic seizures. Participants with NCC were more likely to experience epileptic seizures (OR = 3.98, 95% CI 1.34–11.78, p = 0.01) than those without NCC, although only 7/45 (16%) people with NCC ever experienced epileptic seizures. The number of lesions did not differ by TS POC CC status (median: 3 [IQR 1–6] versus 2.5 [IQR 1–5.3], p = 0.64). Eight (23%) of the 35 TS POC CC+ participants with NCC had active stage lesions; in ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://repository.publisso.de/resource/frl:6519983; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444043/ |
| DOI: |
10.1007/s44197-024-00271-z |
| Availability: |
https://repository.publisso.de/resource/frl:6519983; https://doi.org/10.1007/s44197-024-00271-z; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444043/ |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.6EF4B043 |
| Database: |
BASE |