| Title: |
Genome wide conditional mouse knockout resources |
| Authors: |
Kaloff, C; Anastassiadis, K; Ayadi, A; Baldock, R; Beig, J; Birling, M-C; Bradley, A; Brown, SDM; Bürger, A; Bushell, W; Chiani, F; Collins, FS; Doe, B; Eppig, JT; Finnell, RH; Fletcher, C; Flicek, P; Fray, M; Friedel, RH; Gambadoro, A; Gates, H; Hansen, J; Herault, Y; Hicks, GG; Hörlein, A; de Angelis, M Hrabé; Iyer, V; de Jong, PJ; Koscielny, G; Kühn, R; Liu, P; Lloyd, KCK; Lopez, RG; Marschall, S; Martínez, S; McKerlie, C; Meehan, T; von Melchner, H; Moore, M; Murray, SA; Nagy, A; Nutter, LMJ; Pavlovic, G; Pombero, A; Prosser, H; Ramirez-Solis, R; Ringwald, M; Rosen, B; Rosenthal, N; Rossant, J; Noppinger, P Ruiz; Ryder, E; Skarnes, WC; Schick, J; Schnütgen, F; Schofield, P; Seisenberger, C; Selloum, M; Smedley, D; Simpson, EM; Stewart, AF; Teboul, L; Valentini, GP Tocchini; Valenzuela, D; West, AP; Wurst, W |
| Source: |
Drug Discovery Today Disease Models, vol 20 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2016 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
3214 Pharmacology and Pharmaceutical Sciences (for-2020); 32 Biomedical and Clinical Sciences (for-2020); Human Genome (rcdc); Biotechnology (rcdc); Genetics (rcdc); Stem Cell Research (rcdc); Stem Cell Research - Embryonic - Non-Human (rcdc); 2.6 Resources and infrastructure (aetiology) (hrcs-rac); Generic health relevance (hrcs-hc); 1109 Neurosciences (for); 1115 Pharmacology and Pharmaceutical Sciences (for); Neurology & Neurosurgery (science-metrix) |
| Subject Geographic: |
3 - 12 |
| Description: |
The International Knockout Mouse Consortium (IKMC) developed high throughput gene trapping and gene targeting pipelines that produced mostly conditional mutations of more than 18,500 genes in C57BL/6N mouse embryonic stem (ES) cells which have been archived and are freely available to the research community as a frozen resource. From this unprecedented resource more than 6,000 mutant mouse strains have been produced by the IKMC and mostly the International Mouse Phenotyping Consortium (IMPC). In addition, a cre-driver resource was established including 250 inducible cre-driver mouse strains in a C57BL/6 background. Complementing the cre-driver resource, a collection of comprising 27 cre-driver rAAVs has also been produced. The resources can be easily accessed at the IKMC/IMPC web portal (www.mousephenotype.org). The IKMC/IMPC resource is a standardized reference library of mouse models with defined genetic backgrounds that enables the analysis of gene-disease associations in mice of different genetic makeup and should therefore have a major impact on biomedical research. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt7t4927g7; https://escholarship.org/uc/item/7t4927g7; https://escholarship.org/content/qt7t4927g7/qt7t4927g7.pdf |
| DOI: |
10.1016/j.ddmod.2017.08.002 |
| Availability: |
https://escholarship.org/uc/item/7t4927g7; https://escholarship.org/content/qt7t4927g7/qt7t4927g7.pdf; https://doi.org/10.1016/j.ddmod.2017.08.002 |
| Rights: |
public |
| Accession Number: |
edsbas.6F04CCA3 |
| Database: |
BASE |