| Title: |
IgE plasma cells are transcriptionally and functionally distinct from other isotypes |
| Authors: |
Vecchione, Andrea; Devlin, Joseph; Tasker, Carley; Ramnarayan, Venkat Raman; Haase, Paul; Conde, Eva; Srivastava, Devin; Atwal, Gurinder; Bruhns, Pierre; Murphy, Andrew; Sleeman, Matthew; Limnander, Andre; Lim, Wei Keat; Asrat, Seblewongel; Orengo, Jamie |
| Contributors: |
Regeneron Pharmaceuticals Tarrytown, NY; Anticorps en thérapie et pathologie - Antibodies in Therapy and Pathology; Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité); This study was funded by Regeneron Pharmaceuticals. |
| Source: |
ISSN: 2470-9468 ; Science Immunology ; https://pasteur.hal.science/pasteur-05269327 ; Science Immunology, 2024, 9 (99), pp.eadm8964. ⟨10.1126/sciimmunol.adm8964⟩. |
| Publisher Information: |
CCSD; American Association for the Advancement of Science (AAAS) |
| Publication Year: |
2024 |
| Subject Terms: |
[SDV]Life Sciences [q-bio] |
| Description: |
International audience ; Understanding the phenotypic and transcriptional signature of immunoglobulin E (IgE)–producing cells is fundamental to plasma cell (PC) biology and development of therapeutic interventions for allergy. Here, using a mouse model of intranasal house dust mite (HDM) exposure, we showed that short-lived IgE PCs emerge in lung draining lymph nodes (dLNs) during early exposure (7 weeks). IgE PCs had distinct surface and gene expression profiles in these different tissues compared with other Ig isotypes. IgE BMPCs up-regulated genes associated with prosurvival and BM homing, whereas IgE dLN PCs expressed genes associated with recent class switching and differentiation. IgE PCs also exhibited higher expression of endoplasmic reticulum (ER) stress and protein coding genes and higher antibody secretion rate when compared with IgG1. Overall, this study highlights the unique developmental path and transcriptional signature of short-lived and long-lived IgE PCs. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/39241058; PUBMED: 39241058 |
| DOI: |
10.1126/sciimmunol.adm8964 |
| Availability: |
https://pasteur.hal.science/pasteur-05269327; https://pasteur.hal.science/pasteur-05269327v1/document; https://pasteur.hal.science/pasteur-05269327v1/file/adm8964_CombinedPDF_v4.pdf; https://doi.org/10.1126/sciimmunol.adm8964 |
| Rights: |
http://creativecommons.org/licenses/by-nc/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.6F0654A5 |
| Database: |
BASE |