| Title: |
Covid-19 and kidney. Role of Sars-cov-2 infection in the induction of renal damage |
| Authors: |
Perrotta, A M; Rotondi, S; Mazzaferro, S; Bosi, L; Letizia, C; Muscaritoli, M; Gigante, A; Salciccia, S; Pasculli, P; Ciardi, M R; Tinti, F; Galani, A; Errigo, F; Menè, P; Cianci, R; Mitterhofer, A P; Mastroianni, C M; Palange, P; Lai, S |
| Contributors: |
Perrotta, A M; Rotondi, S; Mazzaferro, S; Bosi, L; Letizia, C; Muscaritoli, M; Gigante, A; Salciccia, S; Pasculli, P; Ciardi, M R; Tinti, F; Galani, A; Errigo, F; Menè, P; Cianci, R; Mitterhofer, A P; Mastroianni, C M; Palange, P; Lai, S |
| Publication Year: |
2023 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
chronic kidney disease; covid-19; inflammation; renal damage; sars-cov-2 infection |
| Description: |
OBJECTIVE: SARS-CoV-2 causes acute respiratory disease, interstitial and alveolar pneumonia, and involves numerous organs and systems such as the kidney, heart, digestive tract, blood, and nervous system. We aimed to evaluate the incidence of renal manifestations in patients diagnosed with COVID-19 infection. PATIENTS AND METHODS: We performed a monocentric, cross-sectional, observational study, conducted on 114 patients with SARS-CoV-2. Clinical and laboratory parameters [renal function, serum electrolytes, inflammatory state, blood gas analysis, Interleukin 6 (IL-6) and urinalysis] were evaluated. The same values were checked out after two months (T1), however after negativization. RESULTS: We enrolled 114 patients (59 males) with a mean age of 63.8 ± 13.9 years. We found hematuria in 48 patients (55.8%), proteinuria in 33 patients (38.4%), leukocyturia in 61 patients (70.9%), acute kidney injury (AKI) in 28 patients (24.6%), AKI in chronic kidney disease (CKD) in 24 patients (21.1%). Moreover, we found a significant increase of inflammatory indexes as C Reactive Protein (CRP), lactic dehydrogenase (LDH), alpha 1 and alpha 2 globulins with a subsequent reduction at T1 (p = 0.016, p < 0.001, p = 0.005, p = 0.007; respectively). Hemoglobin and erythrocyte values significantly decreased (p < 0.001, p = 0.003, respectively), and we found lymphopenia (p < 0.001). Also, we found elevated levels of the D-Dimer (p < 0.001) and a significant increase in the International Normalized Ratio (INR) (p = 0.038). We also showed a significant improvement after negativization in oxygen partial pressure (p = 0.001) and oxygen saturation (p < 0.001) and a significant increase in pH (p = 0.018) and bicarbonate concentration (p = 0.042). Moreover, we found a significant increase in IL-6 (p = 0.004). Also, we reported mild hyponatremia and hypokalemia with subsequent significant recovery (p < 0.001, p < 0.001, respectively) and mild hypochloremia with a recovery to the limits of statistical significance (p = ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37667963; info:eu-repo/semantics/altIdentifier/wos/WOS:001076331800048; volume:27; issue:16; firstpage:7861; lastpage:7867; numberofpages:7; journal:EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES; https://hdl.handle.net/11573/1693040 |
| DOI: |
10.26355/eurrev_202308_33441 |
| Availability: |
https://hdl.handle.net/11573/1693040; https://doi.org/10.26355/eurrev_202308_33441 |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.6F1C28A6 |
| Database: |
BASE |