| Title: |
Interleukin-8 in Colorectal Cancer: A Systematic Review and Meta-Analysis of Its Potential Role as a Prognostic Biomarker |
| Authors: |
Bazzichetto C.; Milella M.; Zampiva I.; Simionato F.; Amoreo C. A.; Buglioni S.; Pacelli C.; Le Pera L.; Colombo T.; Bria E.; Zeuli M.; Del Bufalo D.; Sperduti I.; Conciatori F. |
| Contributors: |
Bazzichetto, C.; Milella, M.; Zampiva, I.; Simionato, F.; Amoreo, C. A.; Buglioni, S.; Pacelli, C.; Le Pera, L.; Colombo, T.; Bria, E.; Zeuli, M.; Del Bufalo, D.; Sperduti, I.; Conciatori, F. |
| Publisher Information: |
MDPI; ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND |
| Publication Year: |
2022 |
| Collection: |
Sapienza Università di Roma: CINECA IRIS |
| Subject Terms: |
IL-8; advanced CRC; anti-angiogenic drug; chemotherapy; prognosi; tumor–stroma interactions |
| Description: |
Among soluble actors that have emerged as druggable factors, the chemokine interleukin-8 (IL-8) has emerged as a possible determinant of response to immunotherapy and targeted treatment in several cancer types; however, its prognostic/predictive role in colorectal cancer (CRC) remains to be established. We: (i) conducted a systematic review of published literature on IL-8 expression in CRC; (ii) searched public transcriptomics databases; (iii) investigated IL-8 expression, by tumor and infiltrating cells, in a series of CRC samples; and (iv) carried out a meta-analysis of published literature correlating IL-8 expression and CRC prognosis. IL-8 possesses an important role as a mediator of the bidirectional crosstalk between tumor/stromal cells. Transcriptomic analysis indicated that specific IL-8 transcripts were significantly overexpressed in CRC compared to normal colon mucosa. Moreover, in our series we observed a statistically significant correlation between PTEN-loss and IL-8 expression by infiltrating mononuclear and tumor cells. In total, 12 papers met our meta-analysis inclusion criteria, demonstrating that high IL-8 levels significantly correlated with shorter overall survival and progression-free survival. Sensitivity analysis demonstrated a highly significant correlation with outcome for circulating, but not for tissue-detected, IL-8. IL-8 is overexpressed in CRC tissues and differentially produced by tumor or stromal components depending on CRC genetic background. Moreover, circulating IL-8 represents a strong prognostic factor in CRC, suggesting its use in the refining of prognostic CRC assessment and potentially the tailoring of therapeutic strategies in individual CRC patients. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36289899; info:eu-repo/semantics/altIdentifier/wos/WOS:000872610900001; volume:10; issue:10; firstpage:2631; journal:BIOMEDICINES; https://hdl.handle.net/11573/1670563 |
| DOI: |
10.3390/biomedicines10102631 |
| Availability: |
https://hdl.handle.net/11573/1670563; https://doi.org/10.3390/biomedicines10102631 |
| Accession Number: |
edsbas.6F6DC8FA |
| Database: |
BASE |