| Title: |
An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction:the VALIANT registry |
| Authors: |
Velazquez, EJ; Francis, GS; Armstrong, PW; Aylward, PE; Diaz, R; O'Connor, CM; White, HD; Henis, M; Rittenhouse, LM; Kilaru, R; van Gilst, W; Ertl, G; Maggioni, AP; Spac, J; Weaver, WD; Rouleau, JL; McMurray, JJV; Pfeffer, MA; Califf, RM |
| Source: |
Velazquez, EJ, Francis, GS, Armstrong, PW, Aylward, PE, Diaz, R, O'Connor, CM, White, HD, Henis, M, Rittenhouse, LM, Kilaru, R, van Gilst, W, Ertl, G, Maggioni, AP, Spac, J, Weaver, WD, Rouleau, JL, McMurray, JJV, Pfeffer, MA & Califf, RM 2004, 'An international perspective on heart failure and left ventricular systolic dysfunction complicating myocardial infarction : the VALIANT registry', European Heart Journal, vol. 25, no. 21, pp. 1911-1919. https://doi.org/10.1016/j.ehj.2004.08.006 |
| Publication Year: |
2004 |
| Collection: |
University of Groningen research database |
| Subject Terms: |
heart failure; myocardial infarction; prognosis; left ventricular dysfunction; Killip class; CORONARY PROGNOSTIC INDEX; NATIONAL-REGISTRY; RANDOMIZED-TRIALS; EUROPEAN-SOCIETY; VALSARTAN; MORBIDITY; MORTALITY; DETERMINANTS; PREDICTORS; MANAGEMENT |
| Description: |
Aims We analysed the contemporary incidence, outcomes, and predictors of heart failure (HF) and/or left ventricular systolic dysfunction (LVSD) before discharge in patients with acute myocardial infarction (MI). The baseline presence of HF or LVSD, or its development during hospitalisation, increases short- and long-term risk after MI, yet its incidence, predictors, and outcomes have not been well described in a large, international, general. MI population. Methods and results The VALIANT registry included 5573 consecutive MI patients at 84 hospitals in nine countries from 1999 to 2001. A multivariable logistic survival model was constructed using baseline variables to determine the adjusted mortality risk for those with in-hospital HF and/or LVSD. Baseline variables were also tested for associations with in-hospital HF and/or LVSD. Of the 5566 patients analysed, 42% had HF and/or LVSD during hospitalisation. Their in-hospital. mortality rate was 13.0% compared with 2.3% for those without HF and/or without LVSD. After adjustment for other baseline risk factors, in-hospital HF and/or LVSD carried a hazard ratio for inhospital mortality of 4.12 (95% confidence interval: 3.08-5.56). Patients with HF and/or LVSD also had disproportionately higher rates of other cardiovascular events. Conclusions HF and/or LVSD is common in the general contemporary MI population and precedes 80.3% of all in-hospital deaths after MI. Survivors of early MI-associated HF and/or LVSD have more complications, Longer hospitalisations, and are more likely to die during hospitalisation. Although baseline variables can identify MI patients at highest risk for HF and/or LVSD, such patients are less likely to receive indicated procedures and medical therapies. (C) 2004 The European Society of Cardiology. Published by Elsevier Ltd. All rights reserved. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0195-668X; 1522-9645 |
| Relation: |
info:eu-repo/semantics/altIdentifier/wos/000225201500009; info:eu-repo/semantics/altIdentifier/hdl/https://hdl.handle.net/11370/1bbc4643-f868-4673-9dc5-791e4771b3b6; info:eu-repo/semantics/altIdentifier/pissn/0195-668X; info:eu-repo/semantics/altIdentifier/eissn/1522-9645 |
| DOI: |
10.1016/j.ehj.2004.08.006 |
| Availability: |
https://hdl.handle.net/11370/1bbc4643-f868-4673-9dc5-791e4771b3b6; https://research.rug.nl/en/publications/1bbc4643-f868-4673-9dc5-791e4771b3b6; https://doi.org/10.1016/j.ehj.2004.08.006 |
| Rights: |
info:eu-repo/semantics/restrictedAccess |
| Accession Number: |
edsbas.6F6E8970 |
| Database: |
BASE |