| Title: |
Histopathological tumour viability after neoadjuvant chemotherapy influences survival in resected pancreatic cancer: Analysis of early outcome data |
| Authors: |
Townend, P; de Reuver, PR; Chua, TC; Mittal, A; Clark, SJ; Pavlakis, N; Gill, AJ; Samra, JS |
| Publisher Information: |
John Wiley & Sons |
| Publication Year: |
2018 |
| Collection: |
Griffith University: Griffith Research Online |
| Subject Terms: |
Clinical sciences; lymph node; metastasis; neoadjuvant chemotherapy; pancreatic cancer; pancreatoduodenectomy |
| Description: |
Background: Neoadjuvant therapy is increasingly recognized as an effective strategy prior to pancreatoduodenectomy. We investigate the role of neoadjuvant chemotherapy (NAC) followed by surgery and the predictive role of viable residual tumour cells histopathologically on outcomes. Methods: The study population comprised of 195 consecutive patients with pancreatic adenocarcinoma who were treated with either NAC or a surgery-first (SF) strategy. Histopathological viable tumour cells were examined in the NAC patients and clinicopathological factors were correlated with overall survival. Results: Forty-two patients (22%) were treated with NAC and 153 patients (78%) underwent SF. NAC was associated with higher estimated blood loss during surgery (928 mL versus 615 mL; P = 0.004), fewer (65% residual tumour cells was 45% and 90% in patients who had |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
ANZ Journal of Surgery; Townend, P; de Reuver, PR; Chua, TC; Mittal, A; Clark, SJ; Pavlakis, N; Gill, AJ; Samra, JS, Histopathological tumour viability after neoadjuvant chemotherapy influences survival in resected pancreatic cancer: Analysis of early outcome data, ANZ Journal of Surgery, 2018, 88 (3), pp. E167-E172; https://hdl.handle.net/10072/406276 |
| DOI: |
10.1111/ans.13897 |
| Availability: |
https://hdl.handle.net/10072/406276; https://doi.org/10.1111/ans.13897 |
| Rights: |
open access |
| Accession Number: |
edsbas.6F7A117A |
| Database: |
BASE |