Genome-Wide Association Analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits
| Title: | Genome-Wide Association Analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits |
|---|---|
| Authors: | SPELIOTES EK; YERGES-ARMSTRONG LM; WU J; HERNAEZ R; KIM LJ; PALMER CD; GUDNASON V; EIRIKSDOTTIR G; GARCIA ME; LAUNER LJ; NALLS MA; CLARK JM; MITCHELL BD; SHULDINER AR; BUTLER JL; TOMAS M; HOFFMANN U; HWANG SJ; MASSARO JM; O'DONNELL CJ; SAHANI DV; SALOMAA V; SCHADT EE; SCHWARTZ SM; SISCOVICK DS; NASH CRN; MANUNTA P; Lanzani C; GIANT Consortium; MAGIC Investigators; VOIGHT BF; CARR JJ; FEITOSA MF; HARRIS TB; FOX CS; SMITH AV; KAO WH; HIRSCHHORN JN; BORECKI IB; GOLD Consortium |
| Contributors: | Speliotes, Ek; YERGES-ARMSTRONG, Lm; Wu, J; Hernaez, R; Kim, Lj; Palmer, Cd; Gudnason, V; Eiriksdottir, G; Garcia, Me; Launer, Lj; Nalls, Ma; Clark, Jm; Mitchell, Bd; Shuldiner, Ar; Butler, Jl; Tomas, M; Hoffmann, U; Hwang, Sj; Massaro, Jm; O'Donnell, Cj; Sahani, Dv; Salomaa, V; Schadt, Ee; Schwartz, Sm; Siscovick, D; Nash, Crn; Manunta, P; Lanzani, C; Giant, Consortium; Magic, Investigator; Voight, Bf; Carr, Jj; Feitosa, Mf; Harris, Tb; Fox, C; Smith, Av; Kao, Wh; Hirschhorn, Jn; Borecki, Ib; Gold, Consortium |
| Publication Year: | 2011 |
| Description: | Nonalcoholic fatty liver disease (NAFLD) clusters in families, but the only known common genetic variants influencing risk are near PNPLA3. We sought to identify additional genetic variants influencing NAFLD using genome-wide association (GWA) analysis of computed tomography (CT) measured hepatic steatosis, a non-invasive measure of NAFLD, in large population based samples. Using variance components methods, we show that CT hepatic steatosis is heritable (∼26%–27%) in family-based Amish, Family Heart, and Framingham Heart Studies (n = 880 to 3,070). By carrying out a fixed-effects meta-analysis of genome-wide association (GWA) results between CT hepatic steatosis and ∼2.4 million imputed or genotyped SNPs in 7,176 individuals from the Old Order Amish, Age, Gene/Environment Susceptibility-Reykjavik study (AGES), Family Heart, and Framingham Heart Studies, we identify variants associated at genome-wide significant levels (p |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/21423719; info:eu-repo/semantics/altIdentifier/wos/WOS:000288996600006; volume:7; journal:PLOS GENETICS; https://hdl.handle.net/20.500.11768/8769; https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1001324 |
| DOI: | 10.1371/journal.pgen.1001324 |
| Availability: | https://hdl.handle.net/20.500.11768/8769; https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1001324 |
| Rights: | info:eu-repo/semantics/openAccess ; license:Dominio pubblico ; license uri:http://creativecommons.org/publicdomain/zero/1.0/ |
| Accession Number: | edsbas.6F918C8B |
| Database: | BASE |