| Title: |
Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy |
| Authors: |
Salanova, Vicenta; Witt, Thomas; Worth, Robert; Henry, Thomas R; Gross, Robert E; Nazzaro, Jules M; Labar, Douglas; Sperling, Michael R; Sharan, Ashwini; Sandok, Evan; Handforth, Adrian; Stern, John M; Chung, Steve; Henderson, Jaimie M; French, Jacqueline; Baltuch, Gordon; Rosenfeld, William E; Garcia, Paul; Barbaro, Nicholas M; Fountain, Nathan B; Elias, W Jeffrey; Goodman, Robert R; Pollard, John R; Tröster, Alexander I; Irwin, Christopher P; Lambrecht, Kristin; Graves, Nina; Fisher, Robert; Epstein, Charles; King, Jeanne; Osorio, Ivan; Bakay, Roy; Bergen, Donna |
| Source: |
Neurology, vol 84, iss 10 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2015 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
32 Biomedical and Clinical Sciences (for-2020); 3202 Clinical Sciences (for-2020); Epilepsy (rcdc); Neurosciences (rcdc); Neurodegenerative (rcdc); Brain Disorders (rcdc); Clinical Research (rcdc); Neurological (hrcs-hc); Adolescent (mesh); Adult (mesh); Aged (mesh); Anterior Thalamic Nuclei (mesh); Deep Brain Stimulation (mesh); Epilepsies; Partial (mesh); Female (mesh); Follow-Up Studies (mesh); Humans (mesh); Male (mesh); Middle Aged (mesh); Quality of Life (mesh); Severity of Illness Index (mesh); Time Factors (mesh); Treatment Outcome (mesh); Young Adult (mesh); SANTE Study Group |
| Time: |
1017 - 1025 |
| Description: |
OBJECTIVE: To report long-term efficacy and safety results of the SANTE trial investigating deep brain stimulation of the anterior nucleus of the thalamus (ANT) for treatment of localization-related epilepsy. METHODS: This long-term follow-up is a continuation of a previously reported trial of 5- vs 0-V ANT stimulation. Long-term follow-up began 13 months after device implantation with stimulation parameters adjusted at the investigators' discretion. Seizure frequency was determined using daily seizure diaries. RESULTS: The median percent seizure reduction from baseline at 1 year was 41%, and 69% at 5 years. The responder rate (≥50% reduction in seizure frequency) at 1 year was 43%, and 68% at 5 years. In the 5 years of follow-up, 16% of subjects were seizure-free for at least 6 months. There were no reported unanticipated adverse device effects or symptomatic intracranial hemorrhages. The Liverpool Seizure Severity Scale and 31-item Quality of Life in Epilepsy measure showed statistically significant improvement over baseline by 1 year and at 5 years (p < 0.001). CONCLUSION: Long-term follow-up of ANT deep brain stimulation showed sustained efficacy and safety in a treatment-resistant population. CLASSIFICATION OF EVIDENCE: This long-term follow-up provides Class IV evidence that for patients with drug-resistant partial epilepsy, anterior thalamic stimulation is associated with a 69% reduction in seizure frequency and a 34% serious device-related adverse event rate at 5 years. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt7px3f01g; https://escholarship.org/uc/item/7px3f01g; https://escholarship.org/content/qt7px3f01g/qt7px3f01g.pdf |
| DOI: |
10.1212/wnl.0000000000001334 |
| Availability: |
https://escholarship.org/uc/item/7px3f01g; https://escholarship.org/content/qt7px3f01g/qt7px3f01g.pdf; https://doi.org/10.1212/wnl.0000000000001334 |
| Rights: |
public |
| Accession Number: |
edsbas.6FCB1F50 |
| Database: |
BASE |