| Title: |
The Italian tremor Network (TITAN): rationale, design and preliminary findings. |
| Authors: |
Erro, R; Pilotto, A; Esposito, M; Olivola, E; Nicoletti, A; Lazzeri, G; Magistrelli, L; Dallocchio, C; Marchese, R; Bologna, M; Tessitore, A; Misceo, S; Gigante, AF; Terranova, C; Moschella, V; di Biase, L; Di Giacopo, R; Morgante, F; Valentino, F; De Rosa, A; Trinchillo, A; Malaguti, MC; Brusa, L; Matinella, A; Di Biasio, F; Paparella, G; De Micco, R; Contaldi, E; Modugno, N; Di Fonzo, A; Padovani, A; Barone, P; TITAN Study Group |
| Publisher Information: |
Springer |
| Publication Year: |
2022 |
| Collection: |
St George's University of London: Repository |
| Description: |
INTRODUCTION: The recently released classification has revised the nosology of tremor, defining essential tremor (ET) as a syndrome and fueling an enlightened debate about some newly conceptualized entities such as ET-plus. As a result, precise information of demographics, clinical features, and about the natural history of these conditions are lacking. METHODS: The ITAlian tremor Network (TITAN) is a multicenter data collection platform, the aim of which is to prospectively assess, according to a standardized protocol, the phenomenology and natural history of tremor syndromes. RESULTS: In the first year of activity, 679 patients have been recruited. The frequency of tremor syndromes varied from 32% of ET and 41% of ET-plus to less than 3% of rare forms, including focal tremors (2.30%), task-specific tremors (1.38%), isolated rest tremor (0.61%), and orthostatic tremor (0.61%). Patients with ET-plus were older and had a higher age at onset than ET, but a shorter disease duration, which might suggest that ET-plus is not a disease stage of ET. Familial aggregation of tremor and movement disorders was present in up to 60% of ET cases and in about 40% of patients with tremor combined with dystonia. The body site of tremor onset was different between tremor syndromes, with head tremor being most commonly, but not uniquely, associated with dystonia. CONCLUSIONS: The TITAN study is anticipated to provide clinically relevant prospective information about the clinical correlates of different tremor syndromes and their specific outcomes and might serve as a basis for future etiological, pathophysiological, and therapeutic research. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| ISSN: |
1590-3478 |
| Relation: |
https://openaccess.sgul.ac.uk/id/eprint/114392/7/s10072-022-06104-w.pdf; Erro, R; Pilotto, A; Esposito, M; Olivola, E; Nicoletti, A; Lazzeri, G; Magistrelli, L; Dallocchio, C; Marchese, R; Bologna, M; et al. Erro, R; Pilotto, A; Esposito, M; Olivola, E; Nicoletti, A; Lazzeri, G; Magistrelli, L; Dallocchio, C; Marchese, R; Bologna, M; Tessitore, A; Misceo, S; Gigante, AF; Terranova, C; Moschella, V; di Biase, L; Di Giacopo, R; Morgante, F; Valentino, F; De Rosa, A; Trinchillo, A; Malaguti, MC; Brusa, L; Matinella, A; Di Biasio, F; Paparella, G; De Micco, R; Contaldi, E; Modugno, N; Di Fonzo, A; Padovani, A; Barone, P; TITAN Study Group (2022) The Italian tremor Network (TITAN): rationale, design and preliminary findings. Neurol Sci, 43 (9). pp. 5369-5376. ISSN 1590-3478 https://doi.org/10.1007/s10072-022-06104-w SGUL Authors: Morgante, Francesca |
| DOI: |
10.1007/s10072-022-06104-w |
| Availability: |
https://openaccess.sgul.ac.uk/id/eprint/114392/; https://doi.org/10.1007/s10072-022-06104-w |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.6FCCDA08 |
| Database: |
BASE |