| Title: |
Biomarker-confirmed suboptimal adherence to isoniazid preventive therapy among children with HIV in western Kenya |
| Authors: |
Onyango,Dickens Otieno; van der Sande, Marianne A B; Yuen,Courtney M; Were,Joyce; Mecha,Jerphason; Njagi,Lilian N; Panpradist,Nuttada; Matemo,Daniel; Leon,Daniel; Lutz,Barry; Kinuthia,John; John-Stewart,Grace; Lacourse,Sylvia M; Global Health; JC onderzoeksprogramma Cardiovascular Health |
| Publication Year: |
2024 |
| Subject Terms: |
children with HIV; isoniazid preventive therapy; medication adherence; Mycobacterium tuberculosis infection; tuberculosis; urine biomarkers; Taverne; Infectious Diseases; Immunology and Allergy; Immunology; Journal Article |
| Description: |
Objectives:The aim of this study was to assess the level and correlates of biomarker-confirmed adherence to isoniazid (INH) preventive therapy (IPT) among children with HIV (CLHIV).Design:This prospective cohort study assessed adherence among CLHIV on IPT in public sector HIV clinics from 2019 through 2020.Methods:Adherence was assessed by pill counts or caregiver or self-reports, and urine biomarkers (in-house dipstick and Isoscreen). Both urine biomarker tests detect INH metabolites within 48 h of ingestion. Consistent adherence was defined as having positive results on either biomarker at all visits. Correlates of biomarker-confirmed nonadherence at each visit were evaluated using generalized estimating equations. The in-house dipstick was validated using Isoscreen as the reference.Results:Among 97 CLHIV on IPT with adherence assessments, median age was 10 years (IQR 7-13). All were on ART at IPT initiation (median duration 46 months [IQR 4-89]); 81% were virally suppressed ( |
| Document Type: |
article in journal/newspaper |
| File Description: |
text/plain |
| Language: |
English |
| ISSN: |
0269-9370 |
| Relation: |
https://dspace.library.uu.nl/handle/1874/453146 |
| Availability: |
https://dspace.library.uu.nl/handle/1874/453146 |
| Rights: |
info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.6FD146FA |
| Database: |
BASE |