| Title: |
PD-1/PD-L1 blockade, a novel strategy for targeting metastatic colorectal cancer: A systematic review and meta-analysis of randomized trials |
| Authors: |
Rotundo M. S.; Bagnardi V.; Rotundo M.; Comande M.; Zampino M. G. |
| Contributors: |
Rotundo, M; Bagnardi, V; Comande, M; Zampino, M |
| Publisher Information: |
Spandidos Publications; GR |
| Publication Year: |
2022 |
| Collection: |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: |
Colorectal cancer; Immune checkpoint inhibitor; Immunotherapy; Meta-analysi; Programmed cell death protein 1; Programmed death ligand 1 |
| Description: |
Currently, standard treatment of patients with metastatic colorectal cancer (mCRC) comprises chemotherapy (CT) and/or biological therapy (BT) and/or best supportive care (BSC). The present study performed a meta-analysis on five phase II-III randomized clinical trials, which compared CT/BT/BSC as the control arm with the immune checkpoint inhibitors (ICIs) anti-programmed cell death protein 1 (PD-1) or its ligand (PD-L1) alone or in combination with cytotoxic T lymphocyte antigen 4 or mitogen activated protein kinase kinase inhibitors as the experimental arm, to evaluate whether a standard approach could be overcome using the novel target therapy strategy. Pooled hazard ratio (HR) for progression-free survival was 0.95 in favor of the experimental arm [95% confi- dence interval (CI), 0.74-1.22; P=0.68]. Heterogeneity was significant: Cochran's Q, 21.0; P=0.0082; I2 index, 76%. Pooled HR for overall survival was 0.88 in favor of the experimental arm (95% CI, 0.75-1.02; P=0.08). Heterogeneity was not significant (Cochran's Q, 6.0; P=0.31; I2 index, 16%). The present meta-analysis demonstrated a trend toward the improvement of survival by PD-1/PD-L1 blockade in mCRC. Further homogeneous studies are necessary to strengthen these results, beyond the known benefits of ICIs in deficient mismatch repair/high microsatellite instability tumors. |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/35251353; info:eu-repo/semantics/altIdentifier/wos/WOS:000766610600001; volume:23; issue:4; journal:ONCOLOGY LETTERS; https://hdl.handle.net/10281/398248 |
| DOI: |
10.3892/ol.2022.13254 |
| Availability: |
https://hdl.handle.net/10281/398248; https://doi.org/10.3892/ol.2022.13254 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.6FD93397 |
| Database: |
BASE |