| Title: |
The utility of serology for elimination surveillance of trachoma. |
| Authors: |
Pinsent, Amy; Solomon, Anthony W; Bailey, Robin L; Bid, Rhiannon; Cama, Anaseini; Dean, Deborah; Goodhew, Brook; Gwyn, Sarah E; Jack, Kelvin R; Kandel, Ram Prasad; Kama, Mike; Massae, Patrick; Macleod, Colin; Mabey, David CW; Migchelsen, Stephanie; Müller, Andreas; Sandi, Frank; Sokana, Oliver; Taoaba, Raebwebwe; Tekeraoi, Rabebe; Martin, Diana L; White, Michael T |
| Publisher Information: |
Springer Nature |
| Publication Year: |
2018 |
| Collection: |
London School of Hygiene & Tropical Medicine: LSHTM Research Online |
| Description: |
Robust surveillance methods are needed for trachoma control and recrudescence monitoring, but existing methods have limitations. Here, we analyse data from nine trachoma-endemic populations and provide operational thresholds for interpretation of serological data in low-transmission and post-elimination settings. Analyses with sero-catalytic and antibody acquisition models provide insights into transmission history within each population. To accurately estimate sero-conversion rates (SCR) for trachoma in populations with high-seroprevalence in adults, the model accounts for secondary exposure to Chlamydia trachomatis due to urogenital infection. We estimate the population half-life of sero-reversion for anti-Pgp3 antibodies to be 26 (95% credible interval (CrI): 21-34) years. We show SCRs below 0.015 (95% confidence interval (CI): 0.0-0.049) per year correspond to a prevalence of trachomatous inflammation-follicular below 5%, the current threshold for elimination of active trachoma as a public health problem. As global trachoma prevalence declines, we may need cross-sectional serological survey data to inform programmatic decisions. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://researchonline.lshtm.ac.uk/id/eprint/4650839/1/Pinsent-etal-2018-The-utility-of-serology-for-elimination-surveillance-of-trachoma.pdf; Pinsent, Amy ; Solomon, Anthony W; Bailey, Robin L ORCID logo; Bid, Rhiannon; Cama, Anaseini; Dean, Deborah; Goodhew, Brook; Gwyn, Sarah E; Jack, Kelvin R; Kandel, Ram Prasad; +12 more.Kama, Mike; Massae, Patrick; Macleod, Colin; Mabey, David CW ORCID logo; Migchelsen, Stephanie; Müller, Andreas; Sandi, Frank; Sokana, Oliver; Taoaba, Raebwebwe; Tekeraoi, Rabebe; Martin, Diana L; and White, Michael T (2018) The utility of serology for elimination surveillance of trachoma. Nat Commun, 9 (1). 5444-. DOI:10.1038/s41467-018-07852-0 |
| Availability: |
https://researchonline.lshtm.ac.uk/id/eprint/4650839/ |
| Rights: |
cc_by |
| Accession Number: |
edsbas.6FEF5A0B |
| Database: |
BASE |