| Title: |
Obesity differs from diabetes mellitus in antibody and T-cell responses post-COVID-19 recovery |
| Authors: |
Ali, M; Longet, S; Neale, I; Rongkard, P; Chowdhury, FUH; Hill, J; Brown, A; Laidlaw, S; Tipton, T; Hoque, A; Hassan, N; Hackstein, C-P; Adele, S; Delowar Akther, H; Abraham, P; Paul, S; Rahman, MM; Alam, MM; Parvin, S; Mollah, FH; Hoque, MM; Moore, SC; Biswas, SK; Turtle, L; de Silva, TI; Ogbe, A; Frater, J; Barnes, E; Tomic, A; Carroll, MW; Klenerman, P; Kronsteiner, B; Chowdhury, FR; Dunachie, SJ |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
Objective: Obesity and type 2 diabetes (DM) are risk factors for severe coronavirus disease 2019 (COVID-19) outcomes, which disproportionately affect South Asian populations. This study aims to investigate the humoral and cellular immune responses to SARS-CoV-2 in adult COVID-19 survivors with overweight/obesity (Ov/Ob, BMI ≥ 23 kg/m2) and DM in Bangladesh.Methods: In this cross-sectional study, SARS-CoV-2-specific antibody and T-cell responses were investigated in 63 healthy and 75 PCR-confirmed COVID-19 recovered individuals in Bangladesh, during the pre-vaccination first wave of the COVID-19 pandemic in 2020.Results: In COVID-19 survivors, SARS-CoV-2 infection induced robust antibody and T-cell responses, which correlated with disease severity. After adjusting for age, sex, DM status, disease severity, and time since onset of symptoms, Ov/Ob was associated with decreased neutralizing antibody titers, and increased SARS-CoV-2 spike-specific IFN-γ response along with increased proliferation and IL-2 production by CD8 + T cells. In contrast, DM was not associated with SARS-CoV-2-specific antibody and T-cell responses after adjustment for obesity and other confounders.Conclusion: Ov/Ob is associated with lower neutralizing antibody levels and higher T-cell responses to SARS-CoV-2 post-COVID-19 recovery, while antibody or T-cell responses remain unaltered in DM. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
https://doi.org/10.1093/cei/uxae030 |
| DOI: |
10.1093/cei/uxae030 |
| Availability: |
https://doi.org/10.1093/cei/uxae030; https://ora.ox.ac.uk/objects/uuid:b8c024ec-639c-4cfc-b5bb-6bf191207631 |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution (CC BY) |
| Accession Number: |
edsbas.6FFC08DF |
| Database: |
BASE |