| Title: |
T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP |
| Authors: |
Perruzza L.; Gargari G.; Proietti M.; Fosso B.; D'Erchia A. M.; Faliti C. E.; Rezzonico-Jost T.; Scribano D.; Mauri L.; Colombo D.; Pellegrini G.; Moregola A.; Mooser C.; Pesole G.; Nicoletti M.; Norata G. D.; Geuking M. B.; McCoy K. D.; Guglielmetti S.; Grassi F. |
| Contributors: |
Perruzza, L; Gargari, G; Proietti, M; Fosso, B; D'Erchia, A; Faliti, C; Rezzonico-Jost, T; Scribano, D; Mauri, L; Colombo, D; Pellegrini, G; Moregola, A; Mooser, C; Pesole, G; Nicoletti, M; Norata, G; Geuking, M; Mccoy, K; Guglielmetti, S; Grassi, F |
| Publisher Information: |
Cell Press; US |
| Publication Year: |
2017 |
| Collection: |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| Subject Terms: |
ATP; IgA; metabolism; microbiota; P2rx7; T follicular helper cell |
| Description: |
The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28297661; info:eu-repo/semantics/altIdentifier/wos/WOS:000397330000003; volume:18; issue:11; firstpage:2566; lastpage:2575; numberofpages:10; journal:CELL REPORTS; https://hdl.handle.net/10281/452884; http://www.sciencedirect.com/science/journal/22111247 |
| DOI: |
10.1016/j.celrep.2017.02.061 |
| Availability: |
https://hdl.handle.net/10281/452884; https://doi.org/10.1016/j.celrep.2017.02.061; http://www.sciencedirect.com/science/journal/22111247 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative Commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.700588BB |
| Database: |
BASE |