| Title: |
Cabbage and fermented vegetables: From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID‐19 |
| Authors: |
Bousquet, Jean; Anto, Josep; Czarlewski, Wienczyslawa; Haahtela, Tari; Fonseca, Susana; Iaccarino, Guido; Blain, Hubert; Vidal, Alain; Sheikh, Aziz; Akdis, Cezmi; Zuberbier, Torsten; Hamzah Abdul Latiff, Amir; Abdullah, Baharudin; Aberer, Werner; Abusada, Nancy; Adcock, Ian; Afani, Alejandro; Agache, Ioana; Aggelidis, Xenofon; Agustin, Jenifer; Akdis, Mübeccel; Al‐ahmad, Mona; Al‐zahab Bassam, Abou; Alburdan, Hussam; Aldrey‐palacios, Oscar; Alvarez Cuesta, Emilio; Alwan Salman, Hiba; Alzaabi, Ashraf; Amade, Salma; Ambrocio, Gene; Angles, Rosana; Annesi‐maesano, Isabella; Ansotegui, Ignacio; Ara Bardajo, Paula; Arasi, Stefania; Arshad, Hasan; Cristina Artesani, Maria; Asayag, Estrella; Avolio, Francesca; Azhari, Khuzama; Bachert, Claus; Bagnasco, Diego; Baiardini, Ilaria; Bajrović, Nissera; Bakakos, Petros; Bakeyala Mongono, Sergio; Balotro‐torres, Christine; Barba, Sergio; Barbara, Cristina; Barbosa, Elsa; Barreto, Bruno; Bartra, Joan; Bateman, Eric; Battur, Lkhagvaa; Bedbrook, Anna; Bedolla Barajas, Martín; Beghé, Bianca; Bekere, Antra; Bel, Elizabeth; Ben Kheder, Ali; Benson, Mikael; Berghea, Emilia Camelia; Bergmann, Karl‐christian; Bernardini, Roberto; Bernstein, David; Bewick, Mike; Bialek, Slawomir; Białoszewski, Artur; Bieber, Thomas; Billo, Nils; Bilo, Maria Beatrice; Bindslev‐jensen, Carsten; Bjermer, Leif; Bobolea, Irina; Bochenska Marciniak, Malgorzata; Bond, Christine; Boner, Attilio; Bonini, Matteo; Bonini, Sergio; Bosnic‐anticevich, Sinthia; Bosse, Isabelle; Botskariova, Sofia; Bouchard, Jacques; Boulet, Louis‐philippe; Bourret, Rodolphe; Bousquet, Philippe; Braido, Fulvio; Briggs, Andrew; Brightling, Christopher; Brozek, Jan; Brussino, Luisa; Buhl, Roland; Bumbacea, Roxana; Buquicchio, Rosalva; Burguete Cabañas, María‐teresa; Bush, Andrew; Busse, William; Buters, Jeroen; Caballero‐fonseca, Fernan; Calderon, Moïses; Calvo, Mario; Camargos, Paulo; Camuzat, Thierry; Canevari, F.R.; Cano, Antonio; Canonica, G Walter; Capriles‐hulett, Arnaldo; Caraballo, Luis; Cardona, Vicky; Carlsen, Kai‐hakon; Carmon Pirez, Jonas; Caro, Jorge; Carr, Warner; Carreiro‐martins, Pedro; Carreon‐asuncion, Fredelita; Carriazo, Ana‐maria; Casale, Thomas; Castor, Mary‐ann; Castro, Elizabeth; Caviglia, A.G.; Cecchi, Lorenzo; Cepeda Sarabia, Alfonso; Chandrasekharan, Ramanathan; Chang, Yoon‐seok; Chato‐andeza, Victoria; Chatzi, Lida; Chatzidaki, Christina; Chavannes, Niels; Chaves Loureiro, Claudia; Chelninska, Marta; Chen, Yuzhi; Cheng, Lei; Chinthrajah, Sharon; Chivato, Tomas; Chkhartishvili, Ekaterine; Christoff, George; Chrystyn, Henry; Chu, Derek; Chua, Antonio; Chuchalin, Alexander; Chung, Kian Fan; Cicerán, Alberto; Cingi, Cemal; Ciprandi, Giorgio; Cirule, Ieva; Coelho, Ana Carla; Compalati, Enrico; Constantinidis, Jannis; Correia de Sousa, Jaime; Costa, Elisio Manuel; Costa, David; Costa Domínguez, María del Carmen; Coste, André; Cottini, M.; Cox, Linda; Crisci, Carlos; Crivellaro, Maria Angiola; Cruz, Alvaro; Cullen, John; Custovic, Adnan; Cvetkovski, Biljana; d'Amato, Gennaro; Silva, Jane; Dahl, Ronald; Dahlen, Sven‐erik; Daniilidis, Vasilis; Darjazininahhas, Louei; Darsow, Ulf; Davies, Janet; Blay, Frédéric; de Feo, Giulia; de Guia, Eloisa; Los Santos, Chato; de Manuel Keenoy, Esteban; de Vries, Govert; Deleanu, Diana; Demoly, Pascal; Denburg, Judah; Devillier, Philippe; Didier, Alain; Dimic Janjic, Sanja; Dimou, Maria; Dinh‐xuan, Anh Tuan; Djukanovic, Ratko; Do Ceu Texeira, Maria; Dokic, Dejan; Dominguez Silva, Margarita Gabriela; Douagui, Habib; Douladiris, Nikolaos; Doulaptsi, Maria; Dray, Gérard; Dubakiene, Ruta; Dupas, Eve; Durham, Stephen; Duse, Marzia; Dykewicz, Mark; Ebo, Didier; Edelbaher, Natalija; Eiwegger, Thomas; Eklund, Patrik; El‐gamal, Yehia; El‐sayed, Zeinab; El‐sayed, Shereen; El‐seify, Magda; Emuzyte, Regina; Enecilla, Lourdes; Erhola, Marina; Espinoza, Heidilita; Espinoza Contreras, Jesús Guillermo; Farrell, John; Fernandez, Lenora; Fink Wagner, Antje; Fiocchi, Alessandro; Fokkens, Wytske; Lenia, Folletti; Fonseca, Joao; Fontaine, Jean‐françois; Forastiere, Francesco; Fuentes Pèrez, Jose Miguel; Gaerlan–resureccion, Emily; Gaga, Mina; Gálvez Romero, José Luis; Gamkrelidze, Amiran; Garcia, Alexis; García Cobas, Cecilia Yvonne; García Cruz, María de La Luz Hortensia; Gayraud, Jacques; Gelardi, Matteo; Gemicioglu, Bilun; Gennimata, Dimitra; Genova, Sonya; Gereda, José; Gerth van Wijk, Roy; Giuliano, Antonio; Gomez, Maximiliano; González Diaz, Sandra; Gotua, Maia; Grigoreas, Christos; Grisle, Ineta; Gualteiro, Leo; Guidacci, Marta; Guldemond, Nick; Gutter, Zdenek; Guzmán, Antonieta; Halloum, Ramsa; Halpin, David; Hamelmann, Eckard; Hammadi, Suleiman; Harvey, Richard; Heffler, Enrico; Heinrich, Joachim; Hejjaoui, Adnan; Hellquist‐dahl, Birthe; Hernández Velázquez, Luiana; Hew, Mark; Hossny, Elham; Howarth, Peter; Hrubiško, Martin; Huerta Villalobos, Yunuen Rocío; Humbert, Marc; Salina, Husain; Hyland, Michael; Ibrahim, Moustafa; Ilina, Nataliya; Illario, Maddalena; Incorvaia, Cristoforo; Infantino, Antonio; Irani, Carla; Ispayeva, Zhanat; Ivancevich, Juan‐carlos; E.J. Jares, Edgardo; Jarvis, Deborah; Jassem, Ewa; Jenko, Klemen; Jiméneracruz Uscanga, Rubén Darío; Johnston, Sebastian; Joos, Guy; Jošt, Maja; Julge, Kaja; Jung, Ki‐suck; Just, Jocelyne; Jutel, Marek; Kaidashev, Igor; Kalayci, Omer; Kalyoncu, Fuat; Kapsali, Jeni; Kardas, Przemyslaw; Karjalainen, Jussi; Kasala, Carmela; Katotomichelakis, Michael; Kavaliukaite, Loreta; Kazi, Bennoor; Keil, Thomas; Keith, Paul; Khaitov, Musa; Khaltaev, Nikolai; Kim, You‐Young; Kirenga, Bruce; Kleine‐tebbe, Jorg; Klimek, Ludger; Koffi N’goran, Bernard; Kompoti, Evangelia; Kopač, Peter; Koppelman, Gerard; Korenjeverica, Anja; Koskinen, Seppo; Košnik, Mitja; Kostov, Kosta; Kowalski, Marek; Kralimarkova, Tanya; Kramer Vrščaj, Karmen; Kraxner, Helga; Kreft, Samo; Kritikos, Vicky; Kudlay, Dmitry; Kuitunen, Mikael; Kull, Inger; Kuna, Piotr; Kupczyk, Maciej; Kvedariene, Violeta; Kyriakakou, Marialena; Lalek, Nika; Landi, Massimo; Lane, Stephen; Larenas‐linnemann, Désiree; Lau, Susanne; Laune, Daniel; Lavrut, Jorge; Le, Lan; Lenzenhuber, Martina; Lessa, Marcus; Levin, Michael; Li, Jing; Lieberman, Philip; Liotta, Giuseppe; Lipworth, Brian; Liu, Xuandao; Lobo, Rommel; Lodrup Carlsen, Karin; Lombardi, Carlo; Louis, Renaud; Loukidis, Stelios; Lourenço, Olga; Luna Pech, Jorge; Madjar, Bojan; Maggi, Enrico; Magnan, Antoine; Mahboub, Bassam; Mair, Alpana; Mais, Yassin; Maitland van Der Zee, Anke‐hilse; Makela, Mika; Makris, Michael; Malling, Hans‐jorgen; Mandajieva, Mariana; Manning, Patrick; Manousakis, Manolis; Maragoudakis, Pavlos; Marseglia, Gianluigi; Marshall, Gailen; Reza Masjedi, Mohammad; Máspero, Jorge; Matta Campos, Juan José; Maurer, Marcus; Mavale‐manuel, Sandra; Meço, Cem; Melén, Erik; Melioli, Giovanni; Melo‐gomes, Elisabete; Meltzer, Eli; Menditto, Enrica; Menzies‐gow, Andrew; Merk, Hans; Michel, Jean‐pierre; Micheli, Yann; Miculinic, Neven; Midão, Luís; Mihaltan, Florin; Mikos, Nikolaos; Milanese, Manlio; Milenkovic, Branislava; Mitsias, Dimitrios; Moalla, Bassem; Moda, Giuliana; Mogica Martínez, María Dolores; Mohammad, Yousser; Moin, Mostafa; Molimard, Mathieu; Momas, Isabelle; Mommers, Monique; Monaco, Alessandro; Montefort, Steve; Mora, Dory; Morais‐almeida, Mario; Mösges, Ralph; Mostafa, Badreldin; Mullol, Joaquim; Münter, Lars; Muraro, Antonella; Murray, Ruth; Musarra, Antonio; Mustakov, Tihomir; Naclerio, Robert; Nadeau, Kari; Nadif, Rachel; Nakonechna, Alla; Namazova‐baranova, Leyla; Navarro‐locsin, Gretchen; Neffen, Hugo; Nekam, Kristof; Neou, Angelos; Nettis, Eustachio; Neuberger, Daniel; Nicod, Laurent; Nicola, Stefania; Niederberger‐leppin, Verena; Niedoszytko, Marek; Nieto, Antonio; Novellino, Ettore; Nunes, Elizabete; Nyembue, Dieudonné; O’hehir, Robyn; Odjakova, Cvetanka; Ohta, Ken; Okamoto, Yoshitaka; Okubo, Kimi; Oliver, Brian; Onorato, Gabrielle; Pia Orru, Maria; Ouédraogo, Solange; Ouoba, Kampadilemba; Paggiaro, Pier Luigi; Pagkalos, Aris; Pajno, Giovanni; Pala, Gianni; Palaniappan, S.P.; Pali‐schöll, Isabella; Palkonen, Susanna; Palmer, Stephen; Panaitescu Bunu, Carmen; Panzner, Petr; Papadopoulos, Nikos; Papanikolaou, Vasilis; Papi, Alberto; Paralchev, Bojidar; Paraskevopoulos, Giannis; Park, Hae‐sim; Passalacqua, Giovanni; Patella, Vincenzo; Pavord, Ian; Pawankar, Ruby; Pedersen, Soren; Peleve, Susete; Pellegino, Simona; Pereira, Ana; Pérez, Tamara; Perna, Andrea; Peroni, Diego; Pfaar, Oliver; Pham‐thi, Nhân; Pigearias, Bernard; Pin, Isabelle; Piskou, Konstantina; Pitsios, Constantinos; Plavec, Davor; Poethig, Dagmar; Pohl, Wolfgang; Poplas Susic, Antonija; Popov, Todor; Portejoie, Fabienne; Potter, Paul; Poulsen, Lars; Prados‐torres, Alexandra; Prarros, Fotis; Price, David; Prokopakis, Emmanuel; Puggioni, Francesca; Puig‐domenech, Elisa; Puy, Robert; Rabe, Klaus; Raciborski, Filip; Ramos, Josephine; Recto, Marysia; Reda, Shereen; Regateiro, Frederico; Reider, Norbert; Reitsma, Sietze; Repka‐ramirez, Susana; Ridolo, Erminia; Rimmer, Janet; Rivero Yeverino, Daniela; Angelo Rizzo, José; Robalo‐cordeiro, Carlos; Roberts, Graham; Roche, Nicolas; Rodríguez González, Mónica; Rodríguez Zagal, Eréndira; Rolla, Giovanni; Rolland, Christine; Roller‐wirnsberger, Regina; Roman Rodriguez, Miguel; Romano, Antonino; Romantowski, Jan; Rombaux, Philippe; Romualdez, Joel; Rosado‐pinto, Jose; Rosario, Nelson; Rosenwasser, Lanny; Rossi, Oliviero; Rottem, Menachem; Rouadi, Philip; Rovina, Nikoleta; Rozman Sinur, Irma; Ruiz, Mauricio; Ruiz Segura, Lucy Tania; Ryan, Dermot; Sagara, Hironori; Sakai, Daiki; Sakurai, Daiju; Saleh, Wafaa; Salimaki, Johanna; Samitas, Konstantinos; Samolinski, Boleslaw; Sánchez Coronel, María Guadalupe; Sanchez‐borges, Mario; Sanchez‐lopez, Jaime; Sarafoleanu, Codrut; Sarquis Serpa, Faradiba; Sastre‐dominguez, Joaquin; Savi, Eleonora; Sawaf, Bisher; Scadding, Glenis; Scheire, Sophie; Schmid‐grendelmeier, Peter; Schuhl, Juan Francisco; Schunemann, Holger; Schvalbová, Maria; Schwarze, Jorgen; Scichilone, Nicola; Senna, Gianenrico; Sepúlveda, Cecilia; Serrano, Elie; Shields, Mike; Shishkov, Vasil; Siafakas, Nikos; Simeonov, Alexander; Fer Simons, Estelle; Carlos Sisul, Juan; Sitkauskiene, Brigita; Skrindo, Ingelbjorg; Sokličkošak, Tanja; Solé, Dirceu; Sooronbaev, Talant; Soto‐martinez, Manuel; Soto‐quiros, Manuel; Sousa Pinto, Barnaro; Sova, Milan; Soyka, Michael; Specjalski, Krzysztof; Spranger, Otto; Stamataki, Sofia; Stefanaki, Lina; Stellato, Cristiana; Stelmach, Rafael; Strandberg, Timo; Stute, Petra; Subramaniam, Abirami; Suppli Ulrik, Charlotte; Sutherland, Michael; Sylvestre, Silvia; Syrigou, Aikaterini; Taborda Barata, Luis; Takovska, Nadejda; Tan, Rachel; Tan, Frances; Tan, Vincent; Ping Tang, Ing; Taniguchi, Masami; Tannert, Line; Tantilipikorn, Pongsakorn; Tattersall, Jessica; Tesi, Filippo; Thijs, Carel; Thomas, Mike; To, Teresa; Todo‐bom, Ana‐maria; Togias, Alkis; Tomazic, Peter‐valentin; Tomic‐spiric, Vesna; Toppila‐salmi, Sanna; Toskala, Elina; Triggiani, Massimo; Triller, Nadja; Triller, Katja; Tsiligianni, Ioanna; Uberti, M.; Ulmeanu, Ruxandra; Urbancic, Jure; Urrutia Pereira, Marilyn; Vachova, Martina; Valdés, Felipe; Valenta, Rudolf; Valentin Rostan, Marylin; Valero, Antonio; Valiulis, Arunas; Vallianatou, Mina; Valovirta, Erkka; van Eerd, Michiel; van Ganse, Eric; Hage, Marianne; Vandenplas, Olivier; Vasankari, Tuula; Vassileva, Dafina; Velasco Munoz, Cesar; Ventura, Maria Teresa; Vera‐munoz, Cécilia; Vicheva, Dilyana; Vichyanond, Pakit; Vidgren, Petra; Viegi, Giovanni; Vogelmeier, Claus; von Hertzen, Leena; Vontetsianos, Theodoros; Vourdas, Dimitris; Tran Thien Quan, Vu; Wagenmann, Martin; Walker, Samantha; Wallace, Dana; Wang, de Yun; Waserman, Susan; Wickman, Magnus; Williams, Sian; Williams, Dennis; Wilson, Nicola; Wong, Gary; Woo, Kent; Wright, John; Wroczynski, Piotr; Xepapadaki, Paraskevi; Yakovliev, Plamen; Yamaguchi, Masao; Yan, Kwok; Yeow Yap, Yoke; Yawn, Barbara; Yiallouros, Panayiotis; Yorgancioglu, Arzu; Yoshihara, Shigemi; Young, Ian; Yusuf, Osman; Zaidi, Asghar; Zaitoun, Fares; Zar, Heather; Zedda, M.T.; Zernotti, Mario; Zhang, Luo; Zhong, Nanshan; Zidarn, Mihaela; Zubrinich, Celia |
| Contributors: |
Charité - UniversitätsMedizin = Berlin University Medicine; Humboldt-Universität zu Berlin = Humboldt University of Berlin = Université Humboldt de Berlin (HU Berlin); Berlin Institute of Health (BIH); Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR); Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA); Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office Genève, Suisse (OMS / WHO); Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Instituto de Salud Global - Institute For Global Health Barcelona (ISGlobal); IMIM-Hospital del Mar; Generalitat de Catalunya = Generalidad de Cataluña = Government of Catalonia = Généralité de Catalogne; Universitat Pompeu Fabra Barcelona (UPF); Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health (CIBERESP); Helsinki University Hospital Finland (HUS); Universidade do Porto = University of Porto; University of Naples Federico II = Università degli studi di Napoli Federico II (UNINA); EuroMov - Digital Health in Motion (Euromov DHM); IMT MINES ALÈS; Institut Mines-Télécom Paris (IMT)-Institut Mines-Télécom Paris (IMT)-Université de Montpellier (UM); AgroParisTech; Usher Institute of Population Health Sciences and Informatics Edinburgh, U.K.; The University of Edinburgh; Universität Zürich Zürich = University of Zurich (UZH); Institut Desbrest d'Epidémiologie et de Santé Publique (IDESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM) |
| Source: |
ISSN: 0105-4538. |
| Publisher Information: |
CCSD; Wiley |
| Publication Year: |
2021 |
| Collection: |
Université de Montpellier: HAL |
| Subject Terms: |
sulforaphane; kimchi; fermented vegetable; diet; cabbage; angiotensin-converting enzyme 2; Lactobacillus; COVID-19; MESH: Angiotensin-Converting Enzyme 2; MESH: Antioxidants; MESH: SARS-CoV-2; MESH: Vegetables; MESH: Brassica; MESH: COVID-19; MESH: Diet; MESH: Ecology; MESH: Fermentation; MESH: Gastrointestinal Microbiome; MESH: Humans; MESH: Lactobacillales; MESH: NF-E2-Related Factor 2; [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology |
| Description: |
International audience ; Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT1 R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT1 R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/32762135; PUBMED: 32762135; PUBMEDCENTRAL: PMC7436771 |
| DOI: |
10.1111/all.14549 |
| Availability: |
https://hal.umontpellier.fr/hal-03367962; https://hal.umontpellier.fr/hal-03367962v1/document; https://hal.umontpellier.fr/hal-03367962v1/file/bousquet-all-cabb.pdf; https://doi.org/10.1111/all.14549 |
| Rights: |
https://about.hal.science/hal-authorisation-v1/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.7028BD0 |
| Database: |
BASE |