| Title: |
Assessment of white matter hyperintensity severity using multimodal magnetic resonance imaging |
| Authors: |
Parent, Olivier; Bussy, Aurélie; Devenyi, Gabriel Allan; Dai, Alyssa; Costantino, Manuela; Tullo, Stephanie; Salaciak, Alyssa; Bedford, Saashi; Farzin, Sarah; Béland, Marie-Lise; Valiquette, Vanessa; Villeneuve, Sylvia; Poirier, Judes; Tardif, Christine Lucas; Dadar, Mahsa; Tam, Angela; Labonté, Anne; Binette, Alexa Pichet; Faubert, Anne-Marie; Mathieu, Axel; Madjar, Cécile; Carrier, Charles Edouard; Dansereau, Christian; Kazazian, Christina; Lepage, Claude; Picard, Cynthia; Maillet, David; Michaud, Diane; Couture, Doris; Dea, Doris; Cuello, Claudio; Barkun, Alan; Evans, Alan; Courcot, Blandine; Tardif, Christine; Debacker, Clément; Jack, Clifford R; Fontaine, David; Knopman, David S; Multhaup, Gerhard; Near, Jamie; Leoutsakos, Jeannie-Marie; Maltais, Jean-Robert; Brandt, Jason; Pruessner, Jens; Morris, John C; Breitner, John C S; Cheewakriengkrai, Laksanun; Münter, Lisa-Marie |
| Contributors: |
Fonds de la recherche en sante du Quebec; Alzheimer Society of Canada; Healthy Brains for Healthy Lives; Canada First Research Excellence Fund; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Canadian Institute of Health Research; Jean Louis Levesque Foundation |
| Source: |
Brain Communications ; volume 5, issue 6 ; ISSN 2632-1297 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2023 |
| Description: |
White matter hyperintensities are radiological abnormalities reflecting cerebrovascular dysfunction detectable using MRI. White matter hyperintensities are often present in individuals at the later stages of the lifespan and in prodromal stages in the Alzheimer’s disease spectrum. Tissue alterations underlying white matter hyperintensities may include demyelination, inflammation and oedema, but these are highly variable by neuroanatomical location and between individuals. There is a crucial need to characterize these white matter hyperintensity tissue alterations in vivo to improve prognosis and, potentially, treatment outcomes. How different MRI measure(s) of tissue microstructure capture clinically-relevant white matter hyperintensity tissue damage is currently unknown. Here, we compared six MRI signal measures sampled within white matter hyperintensities and their associations with multiple clinically-relevant outcomes, consisting of global and cortical brain morphometry, cognitive function, diagnostic and demographic differences and cardiovascular risk factors. We used cross-sectional data from 118 participants: healthy controls (n = 30), individuals at high risk for Alzheimer’s disease due to familial history (n = 47), mild cognitive impairment (n = 32) and clinical Alzheimer’s disease dementia (n = 9). We sampled the median signal within white matter hyperintensities on weighted MRI images [T1-weighted (T1w), T2-weighted (T2w), T1w/T2w ratio, fluid-attenuated inversion recovery (FLAIR)] as well as the relaxation times from quantitative T1 (qT1) and T2* (qT2*) images. qT2* and fluid-attenuated inversion recovery signals within white matter hyperintensities displayed different age- and disease-related trends compared to normal-appearing white matter signals, suggesting sensitivity to white matter hyperintensity-specific tissue deterioration. Further, white matter hyperintensity qT2*, particularly in periventricular and occipital white matter regions, was consistently associated with all types of ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/braincomms/fcad279 |
| DOI: |
10.1093/braincomms/fcad279/52267833/fcad279.pdf |
| Availability: |
https://doi.org/10.1093/braincomms/fcad279; https://academic.oup.com/braincomms/advance-article-pdf/doi/10.1093/braincomms/fcad279/52267833/fcad279.pdf; https://academic.oup.com/braincomms/article-pdf/5/6/fcad279/53898727/fcad279.pdf |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: |
edsbas.703D02C7 |
| Database: |
BASE |