| Title: |
Development and validation of the Neuro-Score: a specific scale to detect and monitor cognitive impairment in kidney or liver transplant recipients |
| Authors: |
Moreso, Francesc; Antonio Pons Miñano, José; Sánchez Fructuoso, Ana; Jacas, Carlos; Alegret, Montserrat; Ferrer, Montserrat; Colmenero, Jordi; Andrés Belmonte, Amado; López Jiménez, Verónica; Pascual, Sonia; Mazuecos Blanca, Auxiliadora; Ventura Galiano, Ana Paz; Cachero, Alba; Rivero, Antonio; Crespo, Marta; Cuadrado, Antonio; Caballero Marcos, Arantxa; Gonzalez Diéguez, Maria Luisa; Almohalla Alvarez, Carolina; Maruri Kareaga, Naroa; Alamo Martinez, Jose M.; Pagano, Giulia; Nuño Santana, Enriqueta; Torres, Irina B.; Pérez Flores, Isabel; Alonso Titos, Juana; Rodríguez Soler, María; Martinez Alarcón, Laura; García Álvarez, Teresa María; Beneyto Castelló, Isabel; Gonzalez Vilatarsana, Emma; Miras, Francesc; Gómez Bravo, Miguel Ángel |
| Source: |
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
| Publisher Information: |
Elsevier BV |
| Publication Year: |
2025 |
| Collection: |
Dipòsit Digital de la Universitat de Barcelona |
| Subject Terms: |
Trastorns de la cognició; Trasplantament renal; Trasplantament hepàtic; Hepatic transplantation; Cognition disorders; Kidney transplantation |
| Description: |
We created and validated the Neuro-Score, a specific scale to detect and monitor cognitive impairment, including mild stages, in kidney or liver transplant recipients. A qualitative study was conducted to define a preliminary set of 62 items. Item reduction was performed using exploratory factor analysis. Confirmatory factor analysis assessed the adequacy of the factorial solution. The total scores of the Neuro-Score and mini-mental state examination were compared. Responsiveness to change was evaluated from visit 1 (baseline) to 2A (18 months later) and temporal stability from visit 2A to 2B (1-2 weeks later). Factor analysis showed 11 factors with an eigenvalue of >1. Confirmatory factor analysis yielded a logical solution with 1 factor and 11 items that explained 27.9% of the variance. The final model showed satisfactory internal consistency (Cronbach alpha- 0.82). A weak negative correlation was found between Neuro-Score and mini-mental state examination total scores (Pearson r--0.12; P-.0095). The Neuro-Score responsiveness to change was demonstrated (P-.022). No significant differences in the total score were observed between visits 2A and 2B, supporting the Neuro-Score temporal stability. The Neuro-Score scale is a simple, reliable, self-administered, easy-to-interpret, and consistent 11-item scale to detect and monitor cognitive impairment in kidney and liver transplant recipients. |
| Document Type: |
article in journal/newspaper |
| File Description: |
11 p.; application/pdf |
| Language: |
English |
| ISSN: |
39880125 |
| Relation: |
Reproducció del document publicat a: https://doi.org/10.1016/j.ajt.2025.01.031; American Journal of Transplantation, 2025, vol. 25, num. 5, p. 1059-1069; https://doi.org/10.1016/j.ajt.2025.01.031; https://hdl.handle.net/2445/221932 |
| Availability: |
https://hdl.handle.net/2445/221932 |
| Rights: |
cc by-nc-nd (c) Moreso, Francesc et al., 2025 ; http://creativecommons.org/licenses/by-nc-nd/3.0/es/ ; info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.70499B0C |
| Database: |
BASE |