New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
| Title: | New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk |
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| Authors: | Lu YC; Day FR; Gustafsson S; Buchkovich ML; Na JB; Bataille V; Cousminer DL; Dastani Z; Drong AW; Esko T; Evans DM; Falchi M; Feitosa MF; Ferreira T; Hedman AK; Haring R; Hysi PG; Iles MM; Justice AE; Kanoni S; Lagou V; Li R; Li X; Locke A; Lu C; Magi R; Perry JRB; Pers TH; Qi QB; Sanna M; Schmidt EM; Scott WR; Shungin D; Teumer A; Vinkhuyzen AAE; Walker RW; Westra HJ; Zhang MF; Zhang WH; Zhao JH; Zhu ZH; Afzal U; Ahluwalia TS; Bakker SJL; Bellis C; Bonnefond A; Borodulin K; Buchman AS; Cederholm T; Choh AC; Choi HJ; Curran JE; de Groot LCPGM; De Jager PL; Dhonukshe-Rutten RAM; Enneman AW; Eury E; Evans DS; Forsen T; Friedrich N; Fumeron F; Garcia ME; Gartner S; Han BG; Havulinna AS; Hayward C; Hernandez D; Hillege H; Ittermann T; Kent JW; Kolcic I; Laatikainen T; Lahti J; Leach IM; Lee CG; Lee JY; Liu T; Liu YF; Lobbens S; Loh M; Lyytikainen LP; Medina-Gomez C; Michaelsson K; Nalls MA; Nielson CM; Oozageer L; Pascoe L; Paternoster L; Polasek O; Ripatti S; Sarzynski MA; Shin CS; Narancic NS; Spira D; Srikanth P; Steinhagen-Thiessen E; Sung YJ; Swart KMA; Taittonen L; Tanaka T; Tikkanen E; van der Velde N; van Schoor NM; Verweij N; Wright AF; Yu L; Zmuda JM; Eklund N; Forrester T; Grarup N; Jackson AU; Kristiansson K; Kuulasmaa T; Kuusisto J; Lichtner P; Luan JA; Mahajan A; Mannisto S; Palmer CD; Ried JS; Scott RA; Stancakova A; Wagner PJ; Demirkan A; Doring A; Gudnason V; Kiel DP; Kuhnel B; Mangino M; Mcknight B; Menni C; O'Connell JR; Oostra BA; Shuldiner AR; Song KJ; Vandenput L; van Duijn CM; Vollenweider P; White CC; Boehnke M; Boettcher Y; Cooper RS; Forouhi NG; Gieger C; Grallert H; Hingorani A; Jorgensen T; Jousilahti P; Kivimaki M; Kumari M; Laakso M; Langenberg C; Linneberg A; Luke A; Mckenzie CA; Palotie A; Pedersen O; Peters A; Strauch K; Tayo BO; Wareham NJ; Bennett DA; Bertram L; Blangero J; Bluher M; Bouchard C; Campbell H; Cho NH; Cummings SR; Czerwinski SA; Demuth I; Eckardt R; Eriksson JG; Ferrucci L; Franco OH; Froguel P; Gansevoort RT; Hansen T; Harris TB; Hastie N; Heliovaara M; Hofman A; Jordan JM; Jula A; Kahonen M; Kajantie E; Knekt PB; Koskinen S; Kovacs P; Lehtimaki T; Lind L; Liu YM; Orwoll ES; Osmond C; Perola M; Perusse L; Raitakari OT; Rankinen T; Rao DC; Rice TK; Rivadeneira F; Rudan I; Salomaa V; Sorensen TIA; Stumvoll M; Tonjes A; Towne B; Tranah GJ; Tremblay A; Uitterlinden AG; van der Harst P; Vartiainen E; Viikari JS; Vitart V; Vohl MC; Volzke H; Walker M; Wallaschofski H; Wild S; Wilson JF; Yengo L; Bishop DT; Borecki IB; Chambers JC; Cupples LA; Dehghan A; Deloukas P; Fatemifar G; Fox C; Furey TS; Franke L; Han JL; Hunter DJ; Karjalainen J; Karpe F; Kaplan RC; Kooner JS; McCarthy MI; Murabito JM; Morris AP; Bishop JAN; North KE; Ohlsson C; Ong KK; Prokopenko I; Richards JB; Schadt EE; Spector TD; Widen E; Willer CJ; Yang J; Ingelsson E; Mohlke KL; Hirschhorn JN; Pospisilik JA; Zillikens MC; Lindgren C; Kilpelainen TO; Loos RJF |
| Contributors: | Y. Lu; F. Day; S. Gustafsson; M. Buchkovich; J. Na; V. Bataille; D. Cousminer; Z. Dastani; A. Drong; T. Esko; D. Evan; M. Falchi; M. Feitosa; T. Ferreira; A. Hedman; R. Haring; P. Hysi; M. Ile; A. Justice; S. Kanoni; V. Lagou; R. Li; X. Li; A. Locke; C. Lu; R. Magi; J. Perry; T. Per; Q. Qi; M. Sanna; E. Schmidt; W. Scott; D. Shungin; A. Teumer; A. Vinkhuyzen; R. Walker; H. Westra; M. Zhang; W. Zhang; J. Zhao; Z. Zhu; U. Afzal; T. Ahluwalia; S. Bakker; C. Belli; A. Bonnefond; K. Borodulin; A. Buchman; T. Cederholm; A. Choh; H. Choi; J. Curran; L. de Groot; P. De Jager; R. Dhonukshe-Rutten; A. Enneman; E. Eury; T. Forsen; N. Friedrich; F. Fumeron; M. Garcia; S. Gartner; B. Han; A. Havulinna; C. Hayward; D. Hernandez; H. Hillege; T. Ittermann; J. Kent; I. Kolcic; T. Laatikainen; J. Lahti; I. Leach; C. Lee; J. Lee; T. Liu; Y. Liu; S. Lobben; M. Loh; L. Lyytikainen; C. Medina-Gomez; K. Michaelsson; M. Nall; C. Nielson; L. Oozageer; L. Pascoe; L. Paternoster; O. Polasek; S. Ripatti; M. Sarzynski; C. Shin; N. Narancic; D. Spira; P. Srikanth; E. Steinhagen-Thiessen; Y. Sung; K. Swart; L. Taittonen; T. Tanaka |
| Publication Year: | 2016 |
| Collection: | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| Subject Terms: | Settore MEDS-24/A - Statistica medica |
| Description: | To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P < 5 x 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk. |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/26833246; info:eu-repo/semantics/altIdentifier/wos/WOS:000371012200002; volume:7; firstpage:1; lastpage:15; numberofpages:15; journal:NATURE COMMUNICATIONS; https://hdl.handle.net/2434/1101508 |
| DOI: | 10.1038/ncomms10495 |
| Availability: | https://hdl.handle.net/2434/1101508; https://doi.org/10.1038/ncomms10495 |
| Rights: | info:eu-repo/semantics/openAccess |
| Accession Number: | edsbas.70FAA53E |
| Database: | BASE |