| Title: |
Blood pressure and cardiovascular risk in relation to birth weight and urinary sodium: An individual-participant meta-Analysis of European family-based population studies |
| Authors: |
Yu Y. L.; Moliterno P.; An D. W.; Raaijmakers A.; Martens D. S.; Stolarz-Skrzypek K.; Tikhonoff V.; Malyutina S.; Casiglia E.; Chori B.; Filipovský J.; Rajzer M.; Allegaert K.; Kawecka-Jaszcz K.; Verhamme P.; Nawrot T. S.; Staessen J. A.; Boggia J. |
| Contributors: |
Yu, Y. L.; Moliterno, P.; An, D. W.; Raaijmakers, A.; Martens, D. S.; Stolarz-Skrzypek, K.; Tikhonoff, V.; Malyutina, S.; Casiglia, E.; Chori, B.; Filipovský, J.; Rajzer, M.; Allegaert, K.; Kawecka-Jaszcz, K.; Verhamme, P.; Nawrot, T. S.; Staessen, J. A.; Boggia, J. |
| Publisher Information: |
LIPPINCOTT WILLIAMS & WILKINS |
| Publication Year: |
2023 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
birth weight; cardiovascular risk; hypertension; total mortality; urinary sodium excretion |
| Description: |
Background: Although the relation of salt intake with blood pressure (BP) is linear, it is U- shaped for mortality and cardiovascular disease (CVD). This individualparticipant meta-analysis explored whether the relation of hypertension, death or CVD with 24-h urinary sodium excretion (UVNA) or sodium-to-potassium (UNAK) ratio was modified by birth weight. Methods: Families were randomly enrolled in the Flemish Study on Genes, Environment and Health Outcomes (19852004) and the European Project on Genes in Hypertension (1999- 2001). Categories of birth weight, UVNA and UNAK (2500-4000, >4000 g; 4.6 g; and 2, respectively) were coded using deviation-from-mean coding and analyzed by Kaplan- Meier survival functions and linear and Cox regression. Results: The study population was subdivided into the Outcome (n = 1945), Hypertension (n = 1460) and Blood Pressure cohorts (n 1/4 1039) to analyze the incidence of mortality and cardiovascular endpoints, hypertension and BP changes as function of UVNA changes. The prevalence of low/medium/high birth weight in the Outcome cohort was 5.8/84.5/9.7%. Over 16.7 years (median), rates were 4.9, 8 and 27.1% for mortality, CVD and hypertension, respectively, but were not associated with birth weight. Multivariable-adjusted hazard ratios were not significant for any endpoint in any of the birth weight, UVNA and UNAK strata. Adult body weight tracked with birth weight (P< 0.0001). The partial r in the low-birth-weight group associating changes from baseline to follow-up in UVNA and SBP was 0.68 (P = 0.023) but not significant in other birth weight groups. Conclusion: This study did not substantiate its prior hypothesis but showed tracking of adult with birth weight and suggest that low birth weight increases salt sensitivity. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/37074387; info:eu-repo/semantics/altIdentifier/wos/WOS:001000477000015; volume:41; issue:7; firstpage:1175; lastpage:1183; numberofpages:9; journal:JOURNAL OF HYPERTENSION; https://hdl.handle.net/11577/3492629 |
| DOI: |
10.1097/HJH.0000000000003447 |
| Availability: |
https://hdl.handle.net/11577/3492629; https://doi.org/10.1097/HJH.0000000000003447 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.70FCF7C7 |
| Database: |
BASE |