| Title: |
Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials |
| Authors: |
Aparicio, Thomas, T.; Ducreux, Michel; Faroux, Roger; Barbier, Emilie; Manfredi, Sylvain; Lecomte, Thierry; Etienne, Pierre-Luc; Bedenne, Laurent; Bennouna, Jaafar; Phélip, Jean-Marc; François, Eric; Michel, Pierre; Legoux, Jean-Louis; Gasmi, Mohamed; Breysacher, Gilles; Rougier, Philippe; de Gramont, Aimery; Lepage, Come; Bouché, Olivier; Seitz, Jean-François; Adenis, Antoine; Alessio, A; Aouakli, A; Azzedine, A; Bedjaoui, A; Bidault, A; Blanchi, A; Botton, A; Cadier-Lagnes, A; Fatisse, A; Gagnaire, A; Gilbert, A; Gueye, A; Hollebecque, A; Lemaire, A; Mahamat, A; Marre, A; Patenotte, A; Rotenberg, A; Roussel, A; Thirot-Bidault, A; Votte, A; Weber, A; Zaanan, A; Dupont-Gossart, Ac; Villing, Al; Queuniet, Am; Coudert, B; Denis, B; Garcia, B; Lafforgue, B; Landi, B; Leduc, B; Linot, B; Paillot, B; Rhein, B; Winkfield, B; Barberis, C; Becht, C; Belletier, C; Berger, C.; Bineau, C; Borel, C; Brezault, C; Buffet, C; Cornila, C; Couffon, C; de La Fouchardière, C; Giraud, C; Lecaille, C; Lepere, C; Lobry, C; Locher, C; Lombard-Bohas, C; Paoletti, C; Platini, C; Rebischung, C; Sarda, C; Vilain, C; Briac-Levaché, C; Auby, D; Baudet-Klepping, D; Bechade, D; Besson, D; Cleau, D; Festin, D; Gargot, D; Genet, D; Goldfain, D; Luet, D; Malka, D; Peré-Vergé, D; Pillon, D; Sevin-Robiche, D; Smith, D; Soubrane, D; Tougeron, D; Zylberait, D; Carola, E; Cuillerier, E; Dorval Danquechin, E; Echinard, E; Janssen, E; Maillard, E; Mitry, E; Norguet-Monnereau, E; Suc, E; Terrebonne, E; Zrihen, E; Pariente, Ea; Almaric, F; Audemar, F; Bonnetain, F; Desseigne, F; Dewaele, F; Di Fiore, F; Ghiringhelli, F; Husseini, F; Khemissa, F; Kikolski, F; Morvan, F; Petit-Laurent, F; Riot, F; Subtil, F; Zerouala-Boussaha, F; Caroli-Bosc, Fx; Boilleau-Jolimoy, G; Bordes, G; Cavaglione, G; Coulanjon, G; Deplanque, G; Gatineau-Saillant, G; Goujon, G; Medinger, G; Roquin, G; Brixi-Benmansour, H; Castanie, H; Lacroix, H; Maechel, H; Perrier, H; Salloum, H; Senellart, H; Baumgaertner, I; Cumin, I; Graber, I; Trouilloud, I; Boutin, J; Butel, J; Charneau, J; Cretin, J; Dauba, J; Deguiral, J; Egreteau, J; Ezenfis, J; Forestier, J; Goineau, J; Lacourt, J; Lafon, J; Martin, J; Meunier, J; Moreau, J; Provencal, J; Taieb, J; Thaury, J; Tuaillon, J; Vergniol, J; Villand, J; Vincent, J; Volet, J; Bachet, Jb; Barbare, Jc; Souquet, Jc; Grangé, Jd; Dor, Jf; Paitel, Jf; Jouve, Jl; Raoul, Jl; Cheula, Jm; Gornet, Jm; Sabate, Jm; Vantelon, Jm; Vaillant, Jn; Aucouturier, Jp; Barbieux, Jp; Herr, Jp; Lafargue, Jp; Lagasse, Jp; Latrive, Jp; Plachot, Jp; Ramain, Jp; Robin, Jp; Spano, Jp; Douillard, Jy; Beerblock, K; Bouhier-Leporrier, K; Slimane Fawzi, K; Cany, L; Chone, L; Dahan, L; Gasnault, L; Rob, L; Wander, L; Baconnier, M; Ben Abdelghani, M; Benchalal, M; Blasquez, M; Carreiro, M; Charbit, M; Combe, M; Duluc, M; Fayolle, M; Gignoux, M; Giovannini, M; Glikmanas, M; Mabro, M; Mignot, M; Mornet, M; Mousseau, M; Mozer, M; Pauwels, M; Pelletier, M; Porneuf, M; Ramdani, M; Schnee, M; Tissot, M; Zawadi, M; Clavero-Fabri, Mc; Gouttebel, Mc; Kaminsky, Mc; Galais, Mp; Abdelli, N; Barrière, N; Bouaria, N; Bouarioua, N; Delas, N; Gérardin, N; Hess-Laurens, N; Stremsdoerfer, N; Berthelet, O; Boulat, O; Capitain, O; Favre, O; Amoyal, P; Bergerault, P; Burtin, P; Cassan, P; Chatrenet, P; Chiappa, P; Claudé, P; Couzigou, P; Feydy, P; Follana, P; Geoffroy, P; Godeau, P; Hammel, P; Laplaige, P; Lehair, P; Martin, P; Novello, P; Pantioni, P; Pienkowski, P; Pouderoux, P; Prost, P; Ruszniewski, P; Souillac, P; Texereau, P; Thévenet, P; Haineaux, Pa; Benoit, R; Coriat, R; Lamy, R; Mackiewicz, R; Beorchia, S; Chaussade, S; Hiret, S; Jacquot, S; Lavau Denes, S; Montembault, S; Nahon, S; Nasca, S; Nguyen, Son; Oddou-Lagraniere, S; Pesque-Penaud, S; Fratte, Sp; Chatellier, T; Mansourbakht, T; Morin, T; Walter, T; Boige, V; Bourgeois, V; Derias, V; Guérin-Meyer, V; Hautefeuille, V; Jestin Le Tallec, V; Lorgis, V; Quentin, V; Sebbagh, V; Veuillez, V; Adhoute, X; Coulaud, X; Becouarn, Y; Coscas, Y; Courouble, Y; Le Bricquir, Y; Molin, Y; Rinaldi, Y; Lam, Yh; Ladhib, Z. |
| Contributors: |
Hopital Saint-Louis AP-HP (AP-HP); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Université Sorbonne Paris Cité (USPC); Université Paris-Saclay; Oncologie digestive Gustave Roussy; Département de médecine oncologique Gustave Roussy (DMO); Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR); Service de gastroentérologie (CHD Vendee - Hopital Les Oudairies, La Roche Sur Yon); Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée); Fédération Francophone de la Cancérologie Digestive, FFCD; Lipides - Nutrition - Cancer Dijon - U1231 (LNC); Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement; Université Bourgogne Franche-Comté COMUE (UBFC); Service d'Hépato-Gastro-Entérologie (CHU de Dijon); Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon); Département d'Hépato-Gastroentérologie CHRU Tours; Centre Hospitalier Régional Universitaire de Tours (CHRU Tours); Hôpital Privé des Côtes d'Armor (HPCA); Institut de Cancérologie de l'Ouest Angers/Nantes (UNICANCER/ICO); UNICANCER; Service de Gastro-entérologie et Hépatologie CHU Saint-Etienne; Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E); Institut de Cancérologie de la Loire Saint-Priest en Jarez; Centre de Lutte contre le Cancer Antoine Lacassagne Nice (UNICANCER/CAL); UNICANCER-Université Côte d'Azur (UniCA); Service d'Hépato-Gastroentérologie CHU Rouen; Hôpital Charles Nicolle Rouen; CHU Rouen; Normandie Université (NU)-Normandie Université (NU)-CHU Rouen; Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN); Normandie Université (NU); Service d'hépato-gastro-entérologie et oncologie digestive CHR Orléans; Centre Hospitalier Regional d'Orléans (CHRO); Service De Gastroenterologie, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille; Hôpital Louis Pasteur Colmar (CH Colmar); Département d'hépato-gastro-entérologie CHU Nantes; Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Institut des Maladies de l’Appareil Digestif CHU Nantes; Service d'oncologie Institut Hospitalier Franco-Britannique : Levallois-Perret; Institut hospitalier Franco-Britannique Levallois-Perret; Hôpital universitaire Robert Debré Reims (CHU Reims); Service d'oncologie digestive et hépato-gastro-entérologie Hôpital de la Timone - APHM; Assistance Publique - Hôpitaux de Marseille (APHM)-Hôpital de la Timone CHU - APHM (TIMONE) |
| Source: |
ISSN: 0959-8049 ; European Journal of Cancer ; https://ube.hal.science/hal-01983308 ; European Journal of Cancer, 2018, 98, pp.1-9. ⟨10.1016/j.ejca.2018.03.031⟩ ; https://www.sciencedirect.com/science/article/pii/S0959804918307809?via%3Dihub. |
| Publisher Information: |
CCSD; Elsevier |
| Publication Year: |
2018 |
| Subject Terms: |
Overweight; Pooled analysis; Prognostic factor; Colorectal cancer; Bevacizumab; [SDV.CAN]Life Sciences [q-bio]/Cancer; [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology |
| Description: |
IF 7.191 (2017) ; International audience ; BACKGROUND:Previous studies showed that high and low body mass index (BMI) was associated with worse prognosis in early-stage colorectal cancer (CRC), and low BMI was associated with worse prognosis in metastatic CRC (mCRC). We aimed to assess efficacy outcomes according to BMI.PATIENTS AND METHODS:A pooled analysis of individual data from 2085 patients enrolled in eight FFCD first-line mCRC trials from 1991 to 2013 was performed. Comparisons were made according to the BMI cut-off: Obese (BMI ≥30), overweight patients (BMI ≥ 25), normal BMI patients (BMI: 18.5-24) and thin patients (BMI |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/29807237; PUBMED: 29807237 |
| DOI: |
10.1016/j.ejca.2018.03.031 |
| Availability: |
https://ube.hal.science/hal-01983308; https://ube.hal.science/hal-01983308v1/document; https://ube.hal.science/hal-01983308v1/file/Overweighted.pdf; https://doi.org/10.1016/j.ejca.2018.03.031 |
| Rights: |
https://creativecommons.org/licenses/by-nc-nd/4.0/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.71090286 |
| Database: |
BASE |