| Title: |
Chitin nanofibrils modulate mechanical response in tympanic membrane replacements |
| Authors: |
Anand S.; Azimi B.; Lucena M.; Ricci C.; Candito M.; Zavagna L.; Astolfi L.; Coltelli M. -B.; Lazzeri A.; Berrettini S.; Moroni L.; Danti S.; Mota C. |
| Contributors: |
Anand, S.; Azimi, B.; Lucena, M.; Ricci, C.; Candito, M.; Zavagna, L.; Astolfi, L.; Coltelli, M. -B.; Lazzeri, A.; Berrettini, S.; Moroni, L.; Danti, S.; Mota, C. |
| Publisher Information: |
Elsevier Ltd |
| Publication Year: |
2023 |
| Collection: |
Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Subject Terms: |
Chitin; Eardrum; Mechanical reinforcement; Nanocomposite; Polysaccharide; Tissue engineering |
| Description: |
The tympanic membrane (TM), is a thin tissue lying at the intersection of the outer and the middle ear. TM perforations caused by traumas and infections often result in a conductive hearing loss. Tissue engineering has emerged as a promising approach for reconstructing the damaged TM by replicating the native material characteristics. In this regard, chitin nanofibrils (CN), a polysaccharide-derived nanomaterial, is known to exhibit excellent biocompatibility, immunomodulation and antimicrobial activity, thereby imparting essential qualities for an optimal TM regeneration. This work investigates the application of CN as a nanofiller for poly(ethylene oxide terephthalate)/poly(butylene terephthalate) (PEOT/PBT) copolymer to manufacture clinically suitable TM scaffolds using electrospinning and fused deposition modelling. The inclusion of CN within the PEOT/PBT matrix showed a three-fold reduction in the corresponding electrospun fiber diameters and demonstrated a significant improvement in the mechanical properties required for TM repair. Furthermore, in vitro biodegradation assay highlighted a favorable influence of CN in accelerating the scaffold degradation over a period of one year. Finally, the oto- and cytocompatibility response of the nanocomposite substrates corroborated their biological relevance for the reconstruction of perforated eardrums. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/36925264; volume:310; firstpage:120732; journal:CARBOHYDRATE POLYMERS; https://hdl.handle.net/11577/3483280 |
| DOI: |
10.1016/j.carbpol.2023.120732 |
| Availability: |
https://hdl.handle.net/11577/3483280; https://doi.org/10.1016/j.carbpol.2023.120732 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.711A41E0 |
| Database: |
BASE |