| Title: |
Symptoms and syndromes associated with SARS-CoV-2 infection and severity in pregnant women from two community cohorts |
| Authors: |
Molteni, E; Astley, CM; Ma, W; Sudre, CH; Magee, LA; Murray, B; Fall, T; Gomez, MF; Tsereteli, N; Franks, PW; Brownstein, JS; Davies, R; Wolf, J; Spector, TD; Ourselin, S; Steves, CJ; Chan, AT; Modat, M |
| Source: |
Scientific Reports , 11 , Article 6928. (2021) |
| Publication Year: |
2021 |
| Collection: |
University College London: UCL Discovery |
| Subject Terms: |
Adolescent; Adult; COVID-19; Cohort Studies; Cross-Sectional Studies; Female; Humans; Mobile Applications; Pregnancy; Pregnancy Complications; Infectious; SARS-CoV-2; Severity of Illness Index; Young Adult |
| Description: |
We tested whether pregnant and non-pregnant women differ in COVID-19 symptom profile and severity, and we extended previous investigations on hospitalized pregnant women to those who did not require hospitalization. Two female community-based cohorts (18-44 years) provided longitudinal (smartphone application, N = 1,170,315, n = 79 pregnant tested positive) and cross-sectional (web-based survey, N = 1,344,966, n = 134 pregnant tested positive) data, prospectively collected through self-participatory citizen surveillance in UK, Sweden and USA. Pregnant and non-pregnant were compared for frequencies of events, including SARS-CoV-2 testing, symptoms and hospitalization rates. Multivariable regression was used to investigate symptoms severity and comorbidity effects. Pregnant and non-pregnant women positive for SARS-CoV-2 infection were not different in syndromic severity, except for gastrointestinal symptoms. Pregnant were more likely to have received testing, despite reporting fewer symptoms. Pre-existing lung disease was most closely associated with syndromic severity in pregnant hospitalized. Heart and kidney diseases and diabetes increased risk. The most frequent symptoms among non-hospitalized women were anosmia [63% pregnant, 92% non-pregnant] and headache [72%, 62%]. Cardiopulmonary symptoms, including persistent cough [80%] and chest pain [73%], were more frequent among pregnant who were hospitalized. Consistent with observations in non-pregnant populations, lung disease and diabetes were associated with increased risk of more severe SARS-CoV-2 infection during pregnancy. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://discovery.ucl.ac.uk/id/eprint/10126285/ |
| Availability: |
https://discovery.ucl.ac.uk/id/eprint/10126285/1/s41598-021-86452-3.pdf; https://discovery.ucl.ac.uk/id/eprint/10126285/ |
| Rights: |
open |
| Accession Number: |
edsbas.711DC25B |
| Database: |
BASE |