| Title: |
Toxicology and Biodegradability of a Phthalate-Free and Bio-Based Novel Plasticizer |
| Authors: |
Simar-Mentières, S.; Nesslany, F.; Sola, M.-L.; Mortier, S.; Raimbault, J.-M.; Gondelle, Franck; Chabot, Laure; Pandard, Pascal; Wils, D.; Chentouf, A. |
| Contributors: |
Laboratoire de toxicologie génétique Lille; Institut Pasteur de Lille; Pasteur Network (Réseau International des Instituts Pasteur)-Pasteur Network (Réseau International des Instituts Pasteur)-Université de Lille; European Research Biology Center (ERBC); Institut National de l'Environnement Industriel et des Risques (INERIS); Roquette Frères; The study was funded by ROQUETTE Frères. |
| Source: |
ISSN: 1687-8191. |
| Publisher Information: |
CCSD; Hindawi |
| Publication Year: |
2021 |
| Collection: |
LillOA (HAL Lille Open Archive, Université de Lille) |
| Subject Terms: |
[SDV.TOX]Life Sciences [q-bio]/Toxicology |
| Description: |
International audience ; Phthalate esters, mainly di-ethylhexylphthalate (DEHP), represent a class of chemicals primarily used as plasticizers for polyvinyl chloride in a wide range of domestic and industrial applications. ese phthalate esters are low-toxicity environmental contaminants. To address these drawbacks, POLYSORB ® ID 37, a blend of diesters obtained from esterification of isosorbide with plant-based fatty acids, was developed. e company can now offer PVC manufacturers a new product which competes with phthalates and other such chemicals. e market for plasticizers is very important, and ROQUETTE intends to provide a more sustainable and safer product. Isosorbide diester is bio-based (made from glucose and vegetable fatty acids). is plasticizer is registered in REACH regulation for high volumes (>1000 T/year). Risk assessment was obtained by conducting a wide range of biodegradability and toxicological protocols, using rodent models, according to established guidelines. Overall, all of the toxicological and biodegradability studies demonstrated that POLYSORB ® ID 37 is nontoxic to mammalian life and is readily biodegradable. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/34335742; PUBMED: 34335742; PUBMEDCENTRAL: PMC8289616 |
| DOI: |
10.1155/2021/9970896 |
| Availability: |
https://ineris.hal.science/ineris-03333614; https://ineris.hal.science/ineris-03333614v1/document; https://ineris.hal.science/ineris-03333614v1/file/2021-090.pdf; https://doi.org/10.1155/2021/9970896 |
| Rights: |
http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess |
| Accession Number: |
edsbas.714B4633 |
| Database: |
BASE |