| Title: |
Parental Age and Severity of Non-Syndromic Orofacial Clefts: Relationship with De Novo Mutations |
| Authors: |
ADAMSON, Olawale; OLADUGBA, Abimbola; ALADE, Azeez; AWOTOYE, Waheed; BUSCH, Tamara; LI, Mary; FASHINA, Azeez; OLOTU, Joy; SULE, Veronica; JAMES, Olutayo; OGUNLEWE, Mobolanle; ADEYEMO, Wasiu; BUTALI, Azeez; IBARRA, Natalie |
| Source: |
Nigerian Dental Journal; Vol. 32 No. 3 (2024): Nigerian Dental Journal ; 3043-6613 ; 0189-1006 ; 10.61172/sptadn71 |
| Publisher Information: |
Nigerian Dental Association |
| Publication Year: |
2025 |
| Subject Terms: |
paternal age; Age; cleft lip and palate; severity |
| Description: |
Background: This study investigates the relationship between paternal and maternal age, and the severity of orofacial clefts and the presence of de novo mutations in children. Methods: This was a retrospective study of individuals who were diagnosed with non-syndromic cleft lip and/or palate (CL/P) and their unaffected parents, from 2012 to 2019. We obtained data from the AfriCRAN project database for Nigerians with non-syndromic orofacial clefts. These individuals were recruited at the Oral and Maxillofacial Surgery Clinic, Lagos University Teaching Hospital, Lagos. Results: There was no statistically significant association between type of CL ± P and parental age in young fathers (p = 0.93). When older fathers were considered, the percentage of complete (more severe) CL ± P cases increased, especially when they were married to older mothers, and this was statistically significant (p = 0.036). In older fathers, the risk of CL ± P in their offspring was increased (OR: 2.66, CI: 1.04-6.80), and there was also an increased risk of developing right-sided CL ± P (OR: 1.61, CI: 1.0-2.59). There was a reduced risk of isolated clefts of the soft palate in younger fathers (OR: 0.36, CI: 0.07–1.71), but the risk increased when considering complete types (more severe) of isolated clefts of the hard and soft palates (OR: 1.63, CI: 0.7–1.7). There was an increase in de novo mutation in children as the difference between paternal and maternal age increased. Conclusion: The study showed that a higher risk of CL ± P and de novo mutations in children is associated with increased parental age. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://nigeriandentaljournal.ng/index.php/ndj/article/view/289/268; https://nigeriandentaljournal.ng/index.php/ndj/article/view/289 |
| DOI: |
10.61172/k2m6rt36 |
| Availability: |
https://nigeriandentaljournal.ng/index.php/ndj/article/view/289; https://doi.org/10.61172/k2m6rt36 |
| Rights: |
Copyright (c) 2024 Olawale ADAMSON, Abimbola OLADUGBA, Azeez ALADE, Waheed AWOTOYE, Tamara BUSCH, Mary LI, Azeez FASHINA, Joy OLOTU, Veronica SULE, Olutayo JAMES, Mobolanle OGUNLEWE, Wasiu ADEYEMO, Azeez BUTALI ; https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.714D4AA9 |
| Database: |
BASE |