| Title: |
Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors |
| Authors: |
Torchia, Jonathon; Golbourn, Brian; Feng, Shengrui; Ho, Ching; Sin-Chan, Patrick; Vasiljevic, Alexandre; Norman, Joseph D; Guilhamon, Paul; Garzia, Livia; Agamez, Natalia R; Lu, Mei; Chan, Tiffany S; Picard, Daniel; de Antonellis, Pasqualino; Khuong-Quang, Dong-Anh; Planello, Aline C; Zeller, Constanze; Barsyte-Lovejoy, Dalia; Lafay-Cousin, Lucie; Letourneau, Louis; Bourgey, Mathieu; Yu, Man; Gendoo, Deena MA; Dzamba, Misko; Barszczyk, Mark; Medina, Tiago; Riemenschneider, Alexandra N; Morrissy, A Sorana; Ra, Young-Shin; Ramaswamy, Vijay; Remke, Marc; Dunham, Christopher P; Yip, Stephen; Ng, Ho-keung; Lu, Jian-Qiang; Mehta, Vivek; Albrecht, Steffen; Pimentel, Jose; Chan, Jennifer A; Somers, Gino R; Faria, Claudia C; Roque, Lucia; Fouladi, Maryam; Hoffman, Lindsey M; Moore, Andrew S; Wang, Yin; Choi, Seung Ah; Hansford, Jordan R; Catchpoole, Daniel; Birks, Diane K; Foreman, Nicholas K; Strother, Doug; Klekner, Almos; Bognár, Laszló; Garami, Miklós; Hauser, Péter; Hortobágyi, Tibor; Wilson, Beverly; Hukin, Juliette; Carret, Anne-Sophie; Van Meter, Timothy E; Hwang, Eugene I; Gajjar, Amar; Chiou, Shih-Hwa; Nakamura, Hideo; Toledano, Helen; Fried, Iris; Fults, Daniel; Wataya, Takafumi; Fryer, Chris; Eisenstat, David D; Scheinemann, Katrin; Fleming, Adam J; Johnston, Donna L; Michaud, Jean; Zelcer, Shayna; Hammond, Robert; Afzal, Samina; Ramsay, David A; Sirachainan, Nongnuch; Hongeng, Suradej; Larbcharoensub, Noppadol; Grundy, Richard G; Lulla, Rishi R; Fangusaro, Jason R; Druker, Harriet; Bartels, Ute; Grant, Ronald; Malkin, David; McGlade, C Jane; Nicolaides, Theodore; Tihan, Tarik; Phillips, Joanna; Majewski, Jacek; Montpetit, Alexandre; Bourque, Guillaume; Bader, Gary D; Reddy, Alyssa T; Gillespie, G Yancey; Warmuth-Metz, Monika |
| Source: |
Cancer Cell, vol 30, iss 6 |
| Publisher Information: |
eScholarship, University of California |
| Publication Year: |
2016 |
| Collection: |
University of California: eScholarship |
| Subject Terms: |
31 Biological Sciences (for-2020); 32 Biomedical and Clinical Sciences (for-2020); 3105 Genetics (for-2020); Rare Diseases (rcdc); Genetics (rcdc); Cancer (rcdc); Pediatric Cancer (rcdc); Cancer Genomics (rcdc); Human Genome (rcdc); Pediatric (rcdc); 2.1 Biological and endogenous factors (hrcs-rac); 5.1 Pharmaceuticals (hrcs-rac); Cell Line; Tumor (mesh); Cell Proliferation (mesh); Cell Survival (mesh); Central Nervous System Neoplasms (mesh); Chromatin (mesh); DNA Methylation (mesh); Dasatinib (mesh); Epigenesis; Genetic (mesh); Epigenomics (mesh); Humans (mesh); Mutation (mesh); Protein Kinase Inhibitors (mesh); Pyrimidines (mesh); Receptor; Platelet-Derived Growth Factor beta (mesh); Rhabdoid Tumor (mesh) |
| Subject Geographic: |
891 - 908 |
| Description: |
We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
qt9zq3v86d; https://escholarship.org/uc/item/9zq3v86d; https://escholarship.org/content/qt9zq3v86d/qt9zq3v86d.pdf |
| DOI: |
10.1016/j.ccell.2016.11.003 |
| Availability: |
https://escholarship.org/uc/item/9zq3v86d; https://escholarship.org/content/qt9zq3v86d/qt9zq3v86d.pdf; https://doi.org/10.1016/j.ccell.2016.11.003 |
| Rights: |
public |
| Accession Number: |
edsbas.717CC2BE |
| Database: |
BASE |