| Title: |
Genetic susceptibility to radiation-induced breast cancer after Hodgkin lymphoma. |
| Authors: |
Opstal-van Winden, AWJ; de Haan, HG; Hauptmann, M; Schmidt, MK; Broeks, A; Russell, NS; Janus, CPM; Krol, ADG; van der Baan, FH; De Bruin, ML; van Eggermond, AM; Dennis, J; Anton-Culver, H; Haiman, CA; Sawyer, EJ; Cox, A; Devilee, P; Hooning, MJ; Peto, J; Couch, FJ; Pharoah, P; Orr, N; Easton, DF; Aleman, BMP; Strong, LC; Bhatia, S; Cooke, R; Robison, LL; Swerdlow, AJ; van Leeuwen, FE |
| Contributors: |
Swerdlow, Anthony |
| Publisher Information: |
AMER SOC HEMATOLOGY |
| Publication Year: |
2019 |
| Collection: |
The Institute of Cancer Research (ICR): Publications Repository |
| Subject Terms: |
Humans; Hodgkin Disease; Breast Neoplasms; Neoplasms; Radiation-Induced; Second Primary; Genetic Predisposition to Disease; Radiotherapy Dosage; Odds Ratio; Risk; Regression Analysis; Case-Control Studies; Genotype; Polymorphism; Single Nucleotide; Quality Control; Adult; Aged; 80 and over; Middle Aged; Female; Young Adult; Cancer Survivors |
| Description: |
Female Hodgkin lymphoma (HL) patients treated with chest radiotherapy (RT) have a very high risk of breast cancer. The contribution of genetic factors to this risk is unclear. We therefore examined 211 155 germline single-nucleotide polymorphisms (SNPs) for gene-radiation interaction on breast cancer risk in a case-only analysis including 327 breast cancer patients after chest RT for HL and 4671 first primary breast cancer patients. Nine SNPs showed statistically significant interaction with RT on breast cancer risk (false discovery rate, |
| Document Type: |
article in journal/newspaper |
| File Description: |
Print-Electronic; 1139; application/pdf |
| Language: |
English |
| ISSN: |
1528-0020; 0006-4971 |
| Relation: |
Blood, 2019, 133 (10), pp. 1130 - 1139; https://repository.icr.ac.uk/handle/internal/3030 |
| Availability: |
https://repository.icr.ac.uk/handle/internal/3030 |
| Rights: |
https://www.rioxx.net/licenses/under-embargo-all-rights-reserved |
| Accession Number: |
edsbas.7180DBAF |
| Database: |
BASE |