| Title: |
Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial |
| Authors: |
Godfrey, Keith M.; Titcombe, Philip; El-Heis, Sarah; Albert, Benjamin B.; Tham, Elizabeth Huiwen; Barton, Sheila J.; Kenealy, Timothy; Chong, Mary Foong-Fong; Nield, Heidi; Chong, Yap Seng; Chan, Shiao-Yng; Cutfield, Wayne S. |
| Publication Year: |
2023 |
| Collection: |
University of Southampton: e-Prints Soton |
| Description: |
Background Maternal vitamin status preconception and during pregnancy has important consequences for pregnancy outcome and offspring development. Changes in vitamin status from preconception through early and late pregnancy and postpartum have been inferred from cross-sectional data, but longitudinal data on vitamin status from preconception throughout pregnancy and postdelivery are sparse. As such, the influence of vitamin supplementation on vitamin status during pregnancy remains uncertain. This study presents one prespecified outcome from the randomized controlled NiPPeR trial, aiming to identify longitudinal patterns of maternal vitamin status from preconception, through early and late pregnancy, to 6 months postdelivery, and determine the influence of vitamin supplementation. Methods and findings In the NiPPeR trial, 1,729 women (from the United Kingdom, Singapore, and New Zealand) aged 18 to 38 years and planning conception were randomized to receive a standard vitamin supplement (control; n = 859) or an enhanced vitamin supplement (intervention; n = 870) starting in preconception and continued throughout pregnancy, with blinding of participants and research staff. Supplement components common to both treatment groups included folic acid, p-carotene, iron, calcium, and iodine; components additionally included in the intervention group were riboflavin, vitamins B6, B12, and D (in amounts available in over-the-counter supplements), myo-inositol, probiotics, and zinc. The primary outcome of the study was glucose tolerance at 28 weeks’ gestation, measured by oral glucose tolerance test. The secondary outcome reported in this study was the reduction in maternal micronutri-ent insufficiency in riboflavin, vitamin B6, vitamin B12, and vitamin D, before and during pregnancy. We measured maternal plasma concentrations of B-vitamins, vitamin D, and markers of insufficiency/deficiency (homocysteine, hydroxykynurenine-ratio, methylmalonic acid) at recruitment, 1 month after commencing intervention preconception, in ... |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.soton.ac.uk/485486/1/journal.pmed.1004260.pdf; Godfrey, Keith M., Titcombe, Philip, El-Heis, Sarah, Albert, Benjamin B., Tham, Elizabeth Huiwen, Barton, Sheila J., Kenealy, Timothy, Chong, Mary Foong-Fong, Nield, Heidi, Chong, Yap Seng, Chan, Shiao-Yng and Cutfield, Wayne S. , NiPPeR Study Group (2023) Maternal B-vitamin and vitamin D status before, during, and after pregnancy and the influence of supplementation preconception and during pregnancy: prespecified secondary analysis of the NiPPeR double-blind randomized controlled trial. PLoS Medicine, 20 (12 December), e1004260, [e1004260]. (doi:10.1371/journal.pmed.1004260 ). |
| Availability: |
https://eprints.soton.ac.uk/485486/; https://eprints.soton.ac.uk/485486/1/journal.pmed.1004260.pdf |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.71B3EB4E |
| Database: |
BASE |