Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia
| Title: | Cognitive and Motor Decline in Dementia with Lewy Bodies and Parkinson's Disease Dementia |
|---|---|
| Authors: | Gonzalez MC; Tovar-Rios DA; Alves G; Dalen I; Williams-Gray CH; Camacho M; Forsgren L; Bäckström D; Lawson RA; Macleod AD; Counsell CE; Paquet C; DeLena C; DAntonio F; Pilotto A; Padovani A; Blanc F; Falup-Pecurariu C; Lewis S; Rejdak K; Papuc A; Hort J; Nedelska Z; O'Brien J; Bonanni L; Marquié M; Abdelnour C; Alcolea D; Beyer K; Aarsland D; Maple-Grødem J |
| Source: | Movement Disorders Clinical Practice |
| Publisher Information: | Wiley |
| Collection: | Newcastle University Library ePrints Service |
| Description: | Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the PICC Cohorts. Methods : The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n=837 and PDD n=157). Results : When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD [-1.8 (CI 95% -2.3;-1.3) vs -1.9 (CI 95% -2.6;-1.2) (p=0.74)]. MDS-UPDRS part III showed nearly identical annual changes [DLB 4.8 (CI 95% 2.1; 7.5)] [PDD 4.8 (CI 95% 2.7; 6.9), (p=0.98)]. Conclusions : DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/290661; https://eprints.ncl.ac.uk/fulltext.aspx?url=290661/CE6FB026-685E-4F04-8849-E94B41C7046C.pdf&pub_id=290661 |
| Availability: | https://eprints.ncl.ac.uk/290661 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.71BA67B6 |
| Database: | BASE |