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Structure-Guided Development of NRAS G12D Inhibitors Based on a 5-Azaindole Core

Title: Structure-Guided Development of NRAS G12D Inhibitors Based on a 5-Azaindole Core
Authors: Cox, Joshua B.; Nair, Vinay; Mandal, Pijus; Reyna, Naphtali; Tran, Tuyen; Mustachio, Lisa Maria; Bardenhagen, Jennifer; Fawver, Janelle; Shepard, Hannah; Hickey, Anna M.; Wu, Qi; Rodriguez, Christian; Yu, Fei; Phan, Phuc; Mendiola, Andrea J.; Johnson, Rebecca; Thapar, Roopa; Johnson, Troy; Jiang, Yongying; Cross, Jason B.; Do, Mary K. Geck; Jones, Philip; Marsalek, Joseph; Heffernan, Timothy; Soth, Michael J.; Nagy, Edith
Contributors: Biological and Environmental Research; Brookhaven National Laboratory; National Institute of General Medical Sciences; Argonne National Laboratory; University of Texas MD Anderson Cancer Center
Source: ACS Medicinal Chemistry Letters ; volume 17, issue 2, page 425-432 ; ISSN 1948-5875 1948-5875
Publisher Information: American Chemical Society (ACS)
Publication Year: 2026
Document Type: article in journal/newspaper
Language: English
DOI: 10.1021/acsmedchemlett.5c00647
Availability: https://doi.org/10.1021/acsmedchemlett.5c00647; https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5c00647
Rights: https://doi.org/10.15223/policy-029 ; https://doi.org/10.15223/policy-037 ; https://doi.org/10.15223/policy-045
Accession Number: edsbas.7232785
Database: BASE