| Title: |
Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction |
| Authors: |
Wood, Greta K.; Sargent, Brendan F.; Ahmad, Zain-Ul-Abideen; Tharmaratnam, Kukatharmini; Dunai, Cordelia; Egbe, Franklyn N.; Martin, Naomi H.; Facer, Bethany; Pendered, Sophie L.; Rogers, Henry C.; Hübel, Christopher; van Wamelen, Daniel J.; Bethlehem, Richard A.I.; Giunchiglia, Valentina; Hellyer, Peter J.; Trender, William; Kalsi, Gursharan; Needham, Edward; Easton, Ava; Jackson, Thomas A.; Cunningham, Colm; Upthegrove, Rachel; Pollak, Thomas A.; Hotopf, Matthew; Solomon, Tom; Pett, Sarah L.; Shaw, Pamela J; Wood, Nicholas; Harrison, Neil A.; Miller, Karla L.; Jezzard, Peter; Williams, Guy; Duff, Eugene P; Williams, Steven; Zelaya, Fernando; Smith, Stephen M.; Keller, Simon; Broome, Matthew; Kingston, Nathalie; Husain, Masud; Vincent, Angela; Bradley, John; Chinnery, Patrick; Menon, David K.; Aggleton, John P.; Nicholson, Timothy R.; Taylor, John-Paul; David, Anthony S.; Carson, Alan; Leek, E. Charles; Galea, Ian |
| Publication Year: |
2024 |
| Collection: |
University of Southampton: e-Prints Soton |
| Description: |
The spectrum, pathophysiology and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the 1-year cognitive, serum biomarker and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who required hospitalization, compared with 2,927 normative matched controls. Cognitive deficits were global, associated with elevated brain injury markers and reduced anterior cingulate cortex volume 1 year after COVID-19. Severity of the initial infective insult, postacute psychiatric symptoms and a history of encephalopathy were associated with the greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies. |
| Document Type: |
article in journal/newspaper |
| File Description: |
text |
| Language: |
English |
| Relation: |
https://eprints.soton.ac.uk/496859/1/s41591-024-03309-8.pdf; Wood, Greta K., Sargent, Brendan F. and Ahmad, Zain-Ul-Abideen , et al. and COVID-CNS Consortium (2024) Posthospitalization COVID-19 cognitive deficits at 1 year are global and associated with elevated brain injury markers and gray matter volume reduction. Nature Medicine. (doi:10.1038/s41591-024-03309-8 ). |
| Availability: |
https://eprints.soton.ac.uk/496859/ |
| Rights: |
cc_by_4 |
| Accession Number: |
edsbas.726DF7A8 |
| Database: |
BASE |