Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study
| Title: | Lithium response in bipolar disorder is associated with focal adhesion and PI3K-Akt networks: a multi-omics replication study |
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| Authors: | Ou AH; Rosenthal SB; Adli M; Akiyama K; Akula N; Alda M; Amare AT; Ardau R; Arias B; Aubry J-M; Backlund L; Bauer M; Baune BT; Bellivier F; Benabarre A; Bengesser S; Bhattacharjee AK; Biernacka JM; Cervantes P; Chen G-B; Chen H-C; Chillotti C; Cichon S; Clark SR; Colom F; Cousins DA; Cruceanu C; Czerski PM; Dantas CR; Dayer A; Del Zompo M; Degenhardt F; DePaulo JR; Etain B; Falkai P; Fellendorf FT; Ferensztajn-Rochowiak E; Forstner AJ; Frisen L; Frye MA; Fullerton JM; Gard S; Garnham JS; Goes FS; Grigoroiu-Serbanescu M; Grof P; Gruber O; Hashimoto R; Hauser J; Heilbronner U; Herms S; Hoffmann P; Hofmann A; Hou L; Jamain S; Jimenez E; Kahn J-P; Kassem L; Kato T; Kittel-Schneider S; Konig B; Kuo P-H; Kusumi I; Lackner N; Laje G; Landen M; Lavebratt C; Leboyer M; Leckband SG; Jaramillo CAL; MacQueen G; Maj M; Manchia M; Marie-Claire C; Martinsson L; Mattheisen M; McCarthy MJ; McElroy SL; McMahon FJ; Mitchell PB; Mitjans M; Mondimore FM; Monteleone P; Nievergelt CM; Nothen MM; Novak T; Osby U; Ozaki N; Papiol S; Perlis RH; Pisanu C; Potash JB; Pfennig A; Reich-Erkelenz D; Reif A; Reininghaus EZ; Rietschel M; Rouleau GA; Rybakowski JK; Schalling M; Schofield PR; Schubert KO; Schulze TG; Schweizer BW; Seemuller F; Severino G; Shekhtman T; Shilling PD; Shimoda K; Simhandl C; Slaney CM; Squassina A; Stamm T; Stopkova P; Tighe SK; Tortorella A; Turecki G; Vieta E; Volkert J; Witt S; Wray NR; Wright A; Young LT; Zandi PP; Kelsoe JR |
| Source: | Translational Psychiatry, December 2024 |
| Publisher Information: | Springer Nature |
| Publication Year: | 2024 |
| Collection: | Newcastle University Library ePrints Service |
| Description: | © The Author(s) 2024.Lithium is the gold standard treatment for bipolar disorder (BD). However, its mechanism of action is incompletely understood, and prediction of treatment outcomes is limited. In our previous multi-omics study of the Pharmacogenomics of Bipolar Disorder (PGBD) sample combining transcriptomic and genomic data, we found that focal adhesion, the extracellular matrix (ECM), and PI3K-Akt signaling networks were associated with response to lithium. In this study, we replicated the results of our previous study using network propagation methods in a genome-wide association study of an independent sample of 2039 patients from the International Consortium on Lithium Genetics (ConLiGen) study. We identified functional enrichment in focal adhesion and PI3K-Akt pathways, but we did not find an association with the ECM pathway. Our results suggest that deficits in the neuronal growth cone and PI3K-Akt signaling, but not in ECM proteins, may influence response to lithium in BD. |
| Document Type: | article in journal/newspaper |
| File Description: | application/pdf |
| Language: | unknown |
| Relation: | https://eprints.ncl.ac.uk/297285; https://eprints.ncl.ac.uk/fulltext.aspx?url=297285/584F5022-1AA5-4EDB-85A7-1EE86C07BAD9.pdf&pub_id=297285 |
| Availability: | https://eprints.ncl.ac.uk/297285 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| Accession Number: | edsbas.728A1E44 |
| Database: | BASE |