| Title: |
A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues |
| Authors: |
Crotty, Kathryn; Anton, Paige; Coleman, Leon G; Morris, Niya L; Lewis, Sloan A; Samuelson, Derrick R; McMahan, Rachel H; Hartmann, Phillipp; Kim, Adam; Ratna, Anuradha; Mandrekar, Pranoti; Wyatt, Todd A; Choudhry, Mashkoor A; Kovacs, Elizabeth J; McCullough, Rebecca; Yeligar, Samantha M |
| Contributors: |
Medicine |
| Source: |
Alcohol, clinical & experimental research ; 47 ; 1 ; 36 ; 44 ; United States |
| Publication Year: |
2024 |
| Collection: |
University of Massachusetts, Medical School: eScholarship@UMMS |
| Subject Terms: |
alcohol use disorder; immunity; inflammation; multi-organ dysfunction |
| Description: |
Alcohol misuse contributes to the dysregulation of immune responses and multiorgan dysfunction across various tissues, which are associated with higher risk of morbidity and mortality in people with alcohol use disorders. Organ-specific immune cells, including microglia in the brain, alveolar macrophages in the lungs, and Kupffer cells in the liver, play vital functions in host immune defense through tissue repair and maintenance of homeostasis. However, binge drinking and chronic alcohol misuse impair these immune cells' abilities to regulate inflammatory signaling and metabolism, thus contributing to multiorgan dysfunction. Further complicating these delicate systems, immune cell dysfunction associated with alcohol misuse is exacerbated by aging and gut barrier leakage. This critical review describes recent advances in elucidating the potential mechanisms by which alcohol misuse leads to derangements in host immunity and highlights current gaps in knowledge that may be the focus of future investigations. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
Alcohol, Clinical and Experimental Research; https://doi.org/10.1111/acer.14979; http://hdl.handle.net/20.500.14038/53192; Alcohol, clinical & experimental research |
| DOI: |
10.1111/acer.14979 |
| Availability: |
https://doi.org/10.1111/acer.14979; https://hdl.handle.net/20.500.14038/53192 |
| Rights: |
This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. © 2022 The Authors. Alcohol: Clinical & Experimental Research published by Wiley Periodicals LLC on behalf of Research Society on Alcohol ; Attribution-NonCommercial-NoDerivatives 4.0 International ; http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Accession Number: |
edsbas.729E56B3 |
| Database: |
BASE |