| Title: |
Valvular and Myocardial Fibroblast Activation in Aortic Stenosis |
| Authors: |
Craig, Neil; McDermott, Michael; Geers, Jolien; Loganath, Krithika; Mahendran, Menaka; Clark, Laura; White, Audrey; Whittington, Beth; Barton, Anna; Balmforth, Craig; Lenell, Joel; Williams, Michelle; van Beek, Edwin; Dey, Damini; Slomka, Piotr; Newby, David; Dweck, Marc |
| Source: |
The PET is Wonderful Journal; Vol. 1 No. 1 (2024): PET is Wonderful 2024 Annual Scientific Meeting Abstracts ; 3049-8902 |
| Publisher Information: |
University of Edinburgh |
| Publication Year: |
2024 |
| Description: |
Activated fibroblasts drive leaflet thickening and left ventricular decompensation in aortic stenosis. Gallium-68 Fibroblast Activation Protein Inhibitor (68Ga-FAPI) binds to these key effector cells, and provides a readout of fibroblast activation. We aimed to describe the role of activated fibroblasts in patients with aortic stenosis in vivo using 68Ga-FAPI. In a prospective observational study, patients with aortic stenosis and control subjects underwent echocardiography, 68Ga-FAPI PET, CT, and MRI. Valvular and myocardial 68Ga-FAPI uptake was quantified using maximal standardised uptake values (SUVmax), and target-to-background ratio (TBRmax). Aortic stenosis severity was measured by peak velocity on echocardiography and the CT calcium score. Myocardial fibrosis was quantified by late gadolinium enhancement (LGE) on MRI. 86 patients with aortic valve disease (72±11 years, 68% male) plus 9 matched control subjects (72±9 years, 67%% male) participated. Increased 68Ga-FAPI uptake was observed in the aortic valves of patients with aortic stenosis compared with controls (p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://journals.ed.ac.uk/PiWJournal/article/view/9967/12812; https://journals.ed.ac.uk/PiWJournal/article/view/9967 |
| DOI: |
10.2218/piwjournal.9967 |
| Availability: |
https://journals.ed.ac.uk/PiWJournal/article/view/9967; https://doi.org/10.2218/piwjournal.9967 |
| Rights: |
Copyright (c) 2024 Neil Craig, Michael McDermott, Jolien Geers, Krithika Loganath, Menaka Mahendran, Laura Clark, Audrey White, Beth Whittington, Anna Barton, Craig Balmforth, Joel Lenell, Michelle Williams, Edwin van Beek, Damini Dey, Piotr Slomka, David Newby, Marc Dweck ; https://creativecommons.org/licenses/by/4.0 |
| Accession Number: |
edsbas.72AE61BC |
| Database: |
BASE |