| Title: |
Seven newly identified loci for autoimmune thyroid disease |
| Authors: |
Cooper, JD; Simmonds, MJ; Walker, NM; Burren, O; Brand, OJ; Guo, H; Wallace, C; Stevens, H; Coleman, G; Franklyn, JA; Todd, JA; Gough, SCL; Aerts, J; Ahmad, T; Arbury, H; Attwood, A; Auton, A; Ball, SG; Balmforth, AJ; Barnes, C; Barrett, JC; Barroso, I; Barton, A; Bennett, AJ; Bhaskar, S; Blaszczyk, K; Bowes, J; Braund, PS; Bredin, F; Breen, G; Brown, MJ; Bruce, IN; Bull, J; Burton, J; Byrnes, J; Caesar, S; Cardin, N; Clee, CM; Coffey, AJ; Connell, JMC; Conrad, DF; Dominiczak, AF; Downes, K; Drummond, HE; Dudakia, D; Dunham, A; Ebbs, B; Eccles, D; Edkins, S; Edwards, C; Elliot, A; Emery, P; Evans, DM; Evans, G; Eyre, S; Farmer, A; Nicol Ferrier, I; Flynn, E; Forbes, A; Forty, L; Frayling, TM; Freathy, RM; Giannoulatou, E; Gibbs, P; Gilbert, P; Gordon-Smith, K; Gray, E; Green, E; Groves, CJ; Grozeva, D; Gwilliam, R; Hall, A; Hammond, N; Hardy, M; Harrison, P; Hassanali, N; Hebaishi, H; Hines, S; Hinks, A; Hitman, GA; Hocking, L; Holmes, C; Howard, E; Howard, P; Howson, JMM; Hughes, D; Hunt, S; Isaacs, JD; Jain, M; Jewell, DP; Johnson, T; Jolley, JD; Jones, IR; Jones, LA; Kirov, G; Langford, CF; Lango-Allen, H; Mark Lathrop, G; Lee, J |
| Publisher Information: |
OXFORD UNIV PRESS |
| Publication Year: |
2012 |
| Collection: |
The University of Melbourne: Digital Repository |
| Description: |
Autoimmune thyroid disease (AITD), including Graves' disease (GD) and Hashimoto's thyroiditis (HT), is one of the most common of the immune-mediated diseases. To further investigate the genetic determinants of AITD, we conducted an association study using a custom-made single-nucleotide polymorphism (SNP) array, the ImmunoChip. The SNP array contains all known and genotype-able SNPs across 186 distinct susceptibility loci associated with one or more immune-mediated diseases. After stringent quality control, we analysed 103 875 common SNPs (minor allele frequency >0.05) in 2285 GD and 462 HT patients and 9364 controls. We found evidence for seven new AITD risk loci (P < 1.12 × 10(-6); a permutation test derived significance threshold), five at locations previously associated and two at locations awaiting confirmation, with other immune-mediated diseases. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| ISSN: |
0964-6906 |
| Relation: |
pii: dds357; https://hdl.handle.net/11343/257174 |
| Availability: |
https://hdl.handle.net/11343/257174 |
| Rights: |
https://creativecommons.org/licenses/by-nc/4.0 ; CC BY-NC |
| Accession Number: |
edsbas.72B98869 |
| Database: |
BASE |