| Title: |
A Comparative Study of Muscle Symptoms of Atorvastatin with Rosuvastatin in Patients of Atherosclerotic Cardiovascular Disease |
| Authors: |
Rashed, Md Rakibul Hasan; Banerjee, Sajal Krishna; Ahsan, Syed Ali; Zaman, SM Mustafa; Ahmed, Khurshed; Rahman, Md Mukhlesur; Mahmood, Manzoor; Arzu, Jahanara; Adhikary, Dipal Krishna; Rabbani, Md Golam Hossain; Amin, Md Rasul; Haque, Md Mustashirul; Mondol, Mohammed Rayhan Masum; Khaled, Md Fakhrul Islam; Kabir, Md Faisal Ibn; Hossain, Md Ashraf; Amin, Md Al; Mohammad Samsuzzaman, Sheikh; Alam, Md Mashiul; Abedin, Md Jainal; Khondoker, Md Noornabi; Hasan, ATM Iqbal; Hoque, Harisul |
| Source: |
University Heart Journal; Vol. 14 No. 1 (2018); 9-20 ; 1998-927X ; 1998-9261 |
| Publisher Information: |
Academic and Research Cell, Department of Cardiology, University Cardiac Centre, BSMMU |
| Publication Year: |
2018 |
| Collection: |
Bangladesh Journals Online (BanglaJOL) |
| Description: |
Background: Statins are the corner stone therapy of atherosclerotic cardiovascular disease (ASCVD). Statins may cause myalgia, myotoxicity, myopathy and rhabdomyolysis along with its lipid lowering properties and pleiotropic effects. Statins associated muscle symptoms (SAMS) are the leading cause of nonadherent and discontinuation. This study was conducted to evaluate and understand the muscle symptoms of high intensity statin therapy (atorvastatin 40 mg and rosuvastatin 20 mg) for a period of three months in individual patient with clinical atherosclerotic cardiovascular disease.Methods: A total of 280 patients with clinical atherosclerotic cardiovascular disease were studied to once daily atorvastatin 40 mg and rosuvastatin 20 mg. It was a randomized controlled single blind trial. The primary end point was muscle symptoms-muscle pain, fatigue, cramp/spasticity and weakness at 4 weeks and in 3 months of study period. Serum creatinine kinase was measured in every patient with muscular symptoms.Results: Patients of atorvastatin group noticed severe pain more than rosuvastatin group at the end of 3 months of treatment period (14.21% vs 4.38%, p |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://banglajol.info/index.php/UHJ/article/view/38481/26184; https://banglajol.info/index.php/UHJ/article/view/38481 |
| Availability: |
https://banglajol.info/index.php/UHJ/article/view/38481 |
| Rights: |
Copyright (c) 2018 University Heart Journal |
| Accession Number: |
edsbas.72D34F99 |
| Database: |
BASE |