| Title: |
Risk stratification using the CHA2DS2-VASc score in Takotsubo syndrome: Data from the Takotsubo Italian network |
| Authors: |
Parodi, Guido; Scudiero, Fernando; Citro, Rodolfo; Silverio, Angelo; Bellandi, Benedetta; Zito, Concetta; Antonini-Canterin, Francesco; Rigo, Fausto; Zocchi, Chiara; Bossone, Eduardo; Salerno-Uriarte, Jorge; Piscione, Federico; Di Mario, Carlo; Armentano, Corinna; Astarita, Costantino; Coppola, Antonino; Ravera, Amelia; Prota, Costantina; Bottiglieri, Pompea; Bovelli, Daniella; Patella, Marco Mariano; Costantino, Marco Fabio; Gregorio, Giovanni; Santoro, Michele; Manganelli, Fiore; Rotondi, Francesco; Del Pace, Stefano; Pascotto, Marco; Grolla, Elisabetta; Tagliamonte, Ercole; Bianchi, Alfredo; Marinosci, Giovanni; Pappalettera, Michele; Pozzi, Andrea; Nardi, Federico; Novo, Giuseppina; Bovenzi, Francesco |
| Contributors: |
Parodi, Guido; Scudiero, Fernando; Citro, Rodolfo; Silverio, Angelo; Bellandi, Benedetta; Zito, Concetta; Antonini-Canterin, Francesco; Rigo, Fausto; Zocchi, Chiara; Bossone, Eduardo; Salerno-Uriarte, Jorge; Piscione, Federico; Di Mario, Carlo; Armentano, Corinna; Astarita, Costantino; Coppola, Antonino; Ravera, Amelia; Prota, Costantina; Bottiglieri, Pompea; Bovelli, Daniella; Patella, Marco Mariano; Costantino, Marco Fabio; Gregorio, Giovanni; Santoro, Michele; Manganelli, Fiore; Rotondi, Francesco; Del Pace, Stefano; Pascotto, Marco; Grolla, Elisabetta; Tagliamonte, Ercole; Bianchi, Alfredo; Marinosci, Giovanni; Pappalettera, Michele; Pozzi, Andrea; Nardi, Federico; Novo, Giuseppina; Bovenzi, Francesco |
| Publisher Information: |
WILEY |
| Publication Year: |
2017 |
| Collection: |
Università degli Studi di Messina: IRIS |
| Subject Terms: |
Anticoagulant; Cardiovascular event; CHA2DS2-VASc score; Stroke; Takotsubo; Takotsubo cardiomyopathy; Takotsubo syndrome; Cardiology and Cardiovascular Medicine |
| Description: |
Background-—The CHA2DS2-VASc score predicts stroke in patients with atrial fibrillation and has been reported to have a prognostic role even in acute coronary syndrome patients. The Takotsubo syndrome is a condition that mimics acute coronary syndrome and may present several complications including stroke. We sought to assess the ability of CHA2DS2-VASc score to predict adverse events in Takotsubo syndrome patients. Methods and Results-—Overall, 371 Takotsubo syndrome patients were enrolled in a prospective registry. Patients were divided into 3 groups according to the CHA2DS2-VASc score: Group A (≤1), B (2–3), and C (≥4). The median CHA2DS2-VASc score was 3 (interquartile range: 2–4). Overall, 9%, 42%, and 49% were included in Group A, B, and C, respectively. Follow-up length was 26`20 months. The mortality rate was 6%, 7%, and 17% in Group A, B, and C, respectively (P=0.011). The stroke rate was 3% and not different among the 3 groups. Estimated major adverse cardiac and cerebrovascular events (the composite of death, myocardial infarction, and stroke) rates in the 3 groups were 6%, 9%, and 17% in Group A, B, and C, respectively (P=0.033). The CHA2DS2-VASc score resulted as a predictor of major adverse cardiac and cerebrovascular events (odds ratio 2.1, 95% confidence interval, 1.2–3.6; P=0.01) and all-cause mortality (odds ratio 1.5, 95% confidence interval, 1.2–1.9; P=0.001). Conclusions-—In Takotsubo syndrome, the CHA2DS2-VASc score allows prediction of cardiovascular events and mortality at long- term follow-up. |
| Document Type: |
article in journal/newspaper |
| File Description: |
ELETTRONICO |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/28912212; info:eu-repo/semantics/altIdentifier/wos/WOS:000411362700028; volume:6; issue:9; firstpage:1; lastpage:6; numberofpages:6; journal:JOURNAL OF THE AMERICAN HEART ASSOCIATION. CARDIOVASCULAR AND CEREBROVASCULAR DISEASE; https://hdl.handle.net/11570/3120964; https://iris.unime.it/bitstream/11570/3120964/1/JAHA 2017.pdf |
| DOI: |
10.1161/JAHA.117.006065 |
| Availability: |
https://hdl.handle.net/11570/3120964; https://doi.org/10.1161/JAHA.117.006065; https://iris.unime.it/bitstream/11570/3120964/1/JAHA 2017.pdf |
| Rights: |
info:eu-repo/semantics/openAccess |
| Accession Number: |
edsbas.72E2EC4E |
| Database: |
BASE |