| Title: |
Transplantation - clinical I |
| Authors: |
Bonani, Marco; Brockmann, Jens; Cohen, Clemens David; Fehr, Thomas; Nocito, Antonio; Schiesser, Marc; Serra, Andreas L.; Blum, Markus; Struker, Marian; Frey, Diana F.; Wüthrich, Rudolf P.; Kim, Yang Wook; Park, Seok Ju; Kim, Tae Hee; Kim, Yeong-Hoon; Kang, Sun Woo; Webb, Lynsey; Casula, Anna; Tomson, Charlie; Ben-Shlomo, Yoav; Mansour, Hany; Akl, Ahmed; Wafa, Ehab; El Shahawy, Mohamed; Palma, Ramiro; Swaminathan, Suda; Irish, Ashley Bruce; Kolonko, Aureliusz; Chudek, Jerzy; Wiecek, Andrzej; Vanrenterghem, Yves; Kuypers, Dirk; Katrien, De Vusser; Evenepoel, Pieter; Claes, Kathleen; Bammens, Bert; Meijers, Björn; Naesens, Maarten; Lo, Stanley; Chan, Ching-Kit; Yong, David; Wong, Ping-Nam; Kwan, Tze-Hoi; Cheng, Yuk-Lun; Fung, Ka-Shun; Choy, Bo-Ying; Chau, Ka-Foon; Leung, Chi-Bong; Ebben, James; Liu, Jiannong; Chen, Shu-Cheng; Collins, Allan; Ho, Yiu-Wing; Abelli, Massimo; Ferrario DI Torvajana, Antonjacopo; Ticozzelli, Elena; Maiga, Benedetta; Patané, Alessandro; Albrizio, Paolo; Gregorini, Marilena; Libetta, Carmelo; Rampino, Teresa; Geraci, Paolo; Dal Canton, Antonio; Rotter, Marie-Therese; Jacobi, Johannes; Pressmar, Katharina; Amann, Kerstin; Eckardt, Kai-Uwe; Weidemann, Alexander; Müller, Karin; Stein, Maik; Diezemann, Claudia; Sefrin, Anett; Babel, Nina; Reinke, Petra; Schachtner, Thomas; Costa, Cristina; Touscoz, Giovanni Antonio; Sidoti, Francesca; Sinesi, Franca; Mantovani, Samantha; Simeone, Salvatore; Balloco, Cinzia; Piasentin Alessio, Elsa; Messina, Maria; Segoloni, Giuseppe; Cavallo, Rossana; Sharma, R .K; Kaul, Dr Anupma; Gupta, R.K.; Gupta, Amit; Prasad, Narayan; Bhadhuria, Dharmendra; Suresh, K J; Benaboud, Sihem; Prié, Dminqiue; Thervet, Eric; Urien, Saik; Legendre, Christophe; Souberbielle, Jean-Claude; Hirt, Déborah; Friedlander, Gérard; Tréluyer, Jean-Marc; Courbebaisse, Marie; Arias, Manuel; Campistol, Josep; Pascual, Julio; Grinyó, Josep Ma; Hernández, Domingo; Morales, JoséMa; Pallardó, Luis Miguel; Serón, Daniel; Senécal, Lynne; Boucher, Anne; Dandavino, Raymond; Colette, Suzon; Vallée, Michel; Lafrance, Jean-Philippe; Tung-Min, Yu; Min-Ju, Wu; Cheng-Hsu, Chen; Chi-Hung, Cheng; Kuo-Hsiung, Shu; Mei-Chin, Wen; Direkze, Shamindra; Khorsavi, Maryam; Stuart, Sam; Goode, Antony; Jones, Gareth; Massimetti, Carlo; Napoletano, Ilaria; Imperato, Gea; Muratore, Maria Teresa; Fazio, Sara; Pessina, Gloria; Brescia, Franco; Feriozzi, Sandro; Tanaka, Kentaro; Sakai, Ken; Futaki, Aki; Hyoudo, Youji; Muramatsu, Masaki; Kawamura, Takeshi; Shishido, Seiichiro; Hara, Shigeko; Kushiyama, Akifumi; Aikawa, Atsushi; Jankowski, Krzysztof; Gozdowska, Jolanta; Lewandowska, Dorota; Kwiatkowski, Artur; Durlik, Magdalena; Pruszczyk, Piotr; Obi, Yoshitsugu; Ichimaru, Naotsugu; Kato, Taigo; Okumi, Masayoshi; Kaimori, Junya; Yazawa, Koji; Nonomura, Norio; Isaka, Yoshitaka; Takahara, Shiro; Aimele, Meftah; Christophe, Ridel; Géraldine, D'ythurbide; Eric, Rondeau; Alexandre, Hertig; Masson, Ingrid; Nicolas, Maillard; Ivan, Tack; Acil, Jaafar; Lise, Thibaudin; Aoumeur, Hadj-Aissa; Laurence, Dubourg; Pierre, Delanaye; Etienne, Cavalier; Lionel, Rostaing; Nassim, Kamar; Emmanuel, Morelon; Eric, Alamartine; Christophe, Mariat; Alexandre, Karras; Pierre, Boutouyrie; Jean-Philippe, Haymann; Dominique, Prie; Christophe, Legendre; Alexei, Girshovitz; Michel, Delahousse; Shah, Pankaj; Kute, Vivek Balkrishna; Vanikar, Aruna; Gumber, Manoj; Modi, Pranjal; Trivedi, Hargovind; GoIebiewska, Justyna; Debska-Slizien, Alicja; Rutkowski, Boleslaw; Domanski, Leszek; Dutkiewicz, Grazyna; Kloda, Karolina; Pawlik, Andrzej; Ciechanowicz, Andrzej; Binczak-Kuleta, Agnieszka; Rozanski, Jacek; Myslak, Marek; Safranow, Krzysztof; Ciechanowski, Kazimierz; Aline, Chabroux Seffert; Basset, Thierry; Delavenne, Xavier; Alamartine, Eric; Mariat, Christophe; Bobrek-Lesiakowska, Katarzyna; Wisniewska, Magda; Romanowski, Maciej; Kurzawski, Mateusz; De Borst, Martin; Baia, Leandro; Navis, Gerjan; Bakker, Stephan; Ranghino, Andrea; Tognarelli, Giuliana; Basso, Elisa; Manzione, Ana Maria; Daidola, Germana; Segoloni, Giuseppe Paolo; Kimura, Takaaki; Yagisawa, Takashi; Ishikawa, Nobuo; Sakuma, Yasunaru; Hujiwara, Takehito; Nukui, Akinori; Yashi, Masahiro; Kim, Ji Hyun; Kim, Sung-Soo; Han, Duck Jong; Park, Su-Kil; Randhawa, Gurch; Patel, Himanshu; Taheri, Saeed; Goker-Alpan, Ozlem; Ibrahim, Jennifer; Nedd, Khan; Shankar, Suma; Lein, Howard; Barshop, Bruce; Boyd, Ellen; Holida, Myrl; Hillman, Richard; Mardach, Rebecca; Wienreb, Neil; Rever, Barbara; Forte, Richard; Desai, Alpana; Wijatyk, Anna; Chang, Peter; Martin, Rick |
| Publisher Information: |
Oxford University Press |
| Publication Year: |
2012 |
| Collection: |
HighWire Press (Stanford University) |
| Subject Terms: |
Abstracts |
| Description: |
Introduction and Aims: Renal allograft recipients are at high risk for bone loss within the first year after transplantation. Receptor Activator of Nuclear factor-Kappa-B Ligand (RANKL) is a key regulator of the activity and survival of osteoclasts. Denosumab (Prolia®) is a humanized monoclonal antibody targeting RANKL, which is effective in the treatment of postmenopausal osteoporosis. Whether Denosumab is effective to prevent bone loss after renal transplantation has not been evaluated. Methods: POSTOP is an ongoing, single center, randomised 1-year trial testing the efficacy and safety of Denosumab to prevent bone loss in kidney allograft recipients on standard triple immunosuppression including steroids. Patients with a functioning graft are recruited within 14 days after transplantation. After bone density measurement, study patients are randomized 1:1 to receive 60 mg Denosumab within 14 days and 6 months after transplantation in addition to standard treatment with calcium/vitamin D or standard treatment alone. Patients with severe osteoporosis (T score < -4) are excluded. The primary endpoint is the change in total hip bone mineral density (BMD) after one year. Secondary endpoints include changes in bone mineral metabolism parameters, incidence of fractures, and allograft function at one year. Results: From June until October 2011 the first 20 patients have been randomized (10 Denosumab vs. 10 control). Their mean age is 52 ± 11years, 8 female (40%) and 12 male (60%), eGFR 55 ± 18 ml/min, DEXA BMD (T score) total hip -0.4 ± 0.9 and lumbar spine -0.6 ± 1.0, DEXA BMD (g/cm2) total hip 0.94 ± 0.11 and lumbar spine 1.01 ± 0.12, calcium 2.32 ± 0.16 mmol/l, phosphate 0.63 ± 0.40 mmol/l, 25-OH Vit. D 17.5 ± 9.9 μg/l, PTH 206.9 ± 197.4 ng/l, mean dose of steroids until randomization 1034 ± 195 mg. So far, no drug-related serious adverse events have been observed. Conclusions: The POSTOP trial represents the first study to investigate whether Denosumab prevents BMD loss in the first year after kidney ... |
| Document Type: |
text |
| File Description: |
text/html |
| Language: |
English |
| Relation: |
http://ndt.oxfordjournals.org/cgi/content/short/27/suppl_2/ii304; http://dx.doi.org/10.1093/ndt/gfs230 |
| DOI: |
10.1093/ndt/gfs230 |
| Availability: |
http://ndt.oxfordjournals.org/cgi/content/short/27/suppl_2/ii304; https://doi.org/10.1093/ndt/gfs230 |
| Rights: |
Copyright (C) 2012, European Renal Association - European Dialysis and Transplant Association |
| Accession Number: |
edsbas.7325BA72 |
| Database: |
BASE |