| Title: |
Gastrinoma and Zollinger-Ellison Syndrome in Canids: A Literature Review and a Case in a Mexican Gray Wolf |
| Authors: |
Struthers, Jason D.; Robl, Nick; Wong, Valerie M.; Kiupel, Matti |
| Contributors: |
SAGE Journals |
| Source: |
Animal, Dairy, and Veterinary Science Student Research |
| Publisher Information: |
Hosted by Utah State University Libraries |
| Publication Year: |
2018 |
| Collection: |
Utah State University: DigitalCommons@USU |
| Subject Terms: |
Canis lupus baileyi; dogs; gastrin; gastrinoma; Mexican gray wolf; neuroendocrine tumor; ulcer; Zollinger–Ellison syndrome; Animal Sciences |
| Description: |
Gastrinoma, an infrequent diagnosis in middle-aged dogs, occurs with nonspecific gastrointestinal morbidity. Laboratory tests can yield a presumptive diagnosis, but definitive diagnosis depends on histopathology and immunohistochemistry. We describe a malignant pancreatic gastrinoma with lymph node metastases and corresponding Zollinger–Ellison syndrome in a Mexican gray wolf (Canis lupus baileyi) and review this endocrine neoplasm in domestic dogs. A 12-y-old, captive, male Mexican gray wolf developed inappetence and weight loss. Abdominal ultrasonography revealed a thickened duodenum and peritoneal effusion. Two duodenal perforations were noted on exploratory celiotomy and were repaired. Persisting clinical signs led to a second celiotomy that revealed a mesenteric mass, which was diagnosed histologically as a neuroendocrine carcinoma. During the following 16 mo, the wolf received a combination of H2-receptor antagonists, proton-pump inhibitors, gastroprotectants, and anti-emetics, but had recurrent episodes of anorexia, nausea, acid reflux, and remained underweight. Worsening clinical signs and weakness prompted euthanasia. The antemortem serum gastrin concentration of 414 ng/L (reference interval: 10–40 ng/L) corroborated hypergastrinemia. Autopsy revealed a mass expanding the right pancreatic limb; 3 parapancreatic mesenteric masses; duodenal ulcers; focal duodenal perforation with septic fibrinosuppurative peritonitis; chronic-active ulcerative esophagitis; and poor body condition. The pancreatic mass was diagnosed histologically as a neuroendocrine carcinoma and the parapancreatic masses as lymph node metastases. Immunohistochemistry of the pancreatic mass was positive for gastrin and negative for glucagon, insulin, pancreatic polypeptide, serotonin, somatostatin, and vasoactive intestinal peptide. |
| Document Type: |
text |
| File Description: |
application/pdf |
| Language: |
unknown |
| Relation: |
https://digitalcommons.usu.edu/advs_stures/10; https://digitalcommons.usu.edu/context/advs_stures/article/1009/viewcontent/1040638718779638.pdf |
| DOI: |
10.1177/1040638718779638 |
| Availability: |
https://digitalcommons.usu.edu/advs_stures/10; https://doi.org/10.1177/1040638718779638; https://digitalcommons.usu.edu/context/advs_stures/article/1009/viewcontent/1040638718779638.pdf |
| Rights: |
Copyright for this work is held by the author. Transmission or reproduction of materials protected by copyright beyond that allowed by fair use requires the written permission of the copyright owners. Works not in the public domain cannot be commercially exploited without permission of the copyright owner. Responsibility for any use rests exclusively with the user. For more information contact the Institutional Repository Librarian at digitalcommons@usu.edu. |
| Accession Number: |
edsbas.732C5D9C |
| Database: |
BASE |