Nodal Burden and Oncologic Outcomes in Patients With Residual Isolated Tumor Cells After Neoadjuvant Chemotherapy (ypN0i+): The OPBC-05/ICARO Study
| Title: | Nodal Burden and Oncologic Outcomes in Patients With Residual Isolated Tumor Cells After Neoadjuvant Chemotherapy (ypN0i+): The OPBC-05/ICARO Study |
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| Authors: | Montagna, Giacomo; Laws, Alison; Ferrucci, Massimo; Mrdutt, Mary M.; Sun, Susie X.; Bademler, Suleyman; Balbaloglu, Hakan; Balint-Lahat, Nora; Banys-Paluchowski, Maggie; Barrio, Andrea V.; Benson, John; Bese, Nuran; Boughey, Judy C.; Boyle, Marissa K.; Diego, Emilia J.; Eden, Claire; Eller, Ruth; Goldschmidt, Maite; Hlavin, Callie; Heidinger, Martin; Jelinska, Justyna; Karadeniz Cakmak, Güldeniz; Kesmodel, Susan B.; King, Tari A.; Kuerer, Henry M.; Loesch, Julie; Milardi, Francesco; Murawa, Dawid; Moo, Tracy-Ann; Menes, Tehillah S.; Passeri, Daniele; Pastoriza, Jessica M.; Perhavec, Andraz; Pislar, Nina; Polidorio, Natália; Rami, Avina; Ryu, Jai Min; Schulz, Alexandra; Sevilimedu, Varadan; Ugurlu, M. Umit; Uras, Cihan; van Hemert, Annemiek; Wong, Stephanie M.; Yoo, Tae-Kyung Robyn; Zhang, Jennifer Q.; Karanlik, Hasan; Cabioğlu, Neslihan; Peeters, Marie-Jeanne Vrancken; Morrow, Monica; Weber, Walter P.; null, null; Ahn, Sung Gwe; Andreozzi, Mariacarla; Barbalho, Daniel Meirelles; Boileau, Jean François; Brogi, Edi; Cabero, Flavia Vidal; Cocco, Daniela; Corsi, Fabio; Crown, Angelena; de Bree, Eelco; del Mar Vernet-Tomas, Maria; Deutschmann, Christine; Ditsch, Nina; Esposito, Emanuela; Fayanju, Oluwadamilola M.; Fick, Franziska; Fitzal, Florian; Flanagan, Meghan R.; Gentile, Damiano; Gentilini, Oreste D.; Grabenstetter, Anne; Gulcelik, Mehmet Ali; Heil, Jörg; Holtschmidt, Johannes; Krawczyk, Natalia; Kühn, Thorsten; Kümmel, Sherko; Leo, Cornelia; Muslumanoglu, Mahmut; Nekljudova, Valentina; Newman, Lisa A.; Pilewskie, Melissa L.; Poulakaki, Fiorita; Riedel, Fabian; Rocco, Nicola; Schnabel, Freya R.; Schwartz, Christopher; Siegel, Emily L.; Simonson, Colin; Singer, Christian; Soares, Leonardo Ribeiro; Christina Tampaki, Ekaterini; Tampakis, Athanasios; Tasoulis, Marios Konstantinos; Tausch, Christoph; Urban, Cicero; Van den Bruele, Astrid Botty; Vergauwen, Glenn; Vorburger, Denise; Wärnberg, Fredrik; Weiss, Anna; Williams, Austin D.; Wimmer, Kerstin; Woodward, Steven G.; Ziauddin, Firdos M. |
| Contributors: | Montagna, Giacomo; Laws, Alison; Ferrucci, Massimo; Mrdutt, Mary M.; Sun, Susie X.; Bademler, Suleyman; Balbaloglu, Hakan; Balint-Lahat, Nora; Banys-Paluchowski, Maggie; Barrio, Andrea V.; Benson, John; Bese, Nuran; Boughey, Judy C.; Boyle, Marissa K.; Diego, Emilia J.; Eden, Claire; Eller, Ruth; Goldschmidt, Maite; Hlavin, Callie; Heidinger, Martin; Jelinska, Justyna; Karadeniz Cakmak, Güldeniz; Kesmodel, Susan B.; King, Tari A.; Kuerer, Henry M.; Loesch, Julie; Milardi, Francesco; Murawa, Dawid; Moo, Tracy-Ann; Menes, Tehillah S.; Passeri, Daniele; Pastoriza, Jessica M.; Perhavec, Andraz; Pislar, Nina; Polidorio, Natália; Rami, Avina; Ryu, Jai Min; Schulz, Alexandra; Sevilimedu, Varadan; Ugurlu, M. Umit; Uras, Cihan; Van Hemert, Annemiek; Wong, Stephanie M.; Yoo, Tae-Kyung Robyn; Zhang, Jennifer Q.; Karanlik, Hasan; Cabioğlu, Neslihan; Peeters, Marie-Jeanne Vrancken; Morrow, Monica; Weber, Walter P.; Null, Null; Ahn, Sung Gwe; Andreozzi, Mariacarla; Barbalho, Daniel Meirelle; Boileau, Jean Françoi; Brogi, Edi; Cabero, Flavia Vidal; Cocco, Daniela; Corsi, Fabio; Crown, Angelena; De Bree, Eelco; del Mar Vernet-Tomas, Maria; Deutschmann, Christine; Ditsch, Nina; Esposito, Emanuela; Fayanju, Oluwadamilola M.; Fick, Franziska; Fitzal, Florian; Flanagan, Meghan R.; Gentile, Damiano; Gentilini, Oreste D.; Grabenstetter, Anne; Gulcelik, Mehmet Ali; Heil, Jörg; Holtschmidt, Johanne; Krawczyk, Natalia; Kühn, Thorsten; Kümmel, Sherko; Leo, Cornelia; Muslumanoglu, Mahmut; Nekljudova, Valentina; Newman, Lisa A.; Pilewskie, Melissa L.; Poulakaki, Fiorita; Riedel, Fabian; Rocco, Nicola; Schnabel, Freya R.; Schwartz, Christopher; Siegel, Emily L.; Simonson, Colin; Singer, Christian; Soares, Leonardo Ribeiro; Christina Tampaki, Ekaterini; Tampakis, Athanasio; Tasoulis, Marios Konstantino; Tausch, Christoph; Urban, Cicero; Van Den Bruele, Astrid Botty; Vergauwen, Glenn; Vorburger, Denise |
| Publisher Information: | Lippincott Williams and Wilkins |
| Publication Year: | 2024 |
| Collection: | Padua Research Archive (IRIS - Università degli Studi di Padova) |
| Description: | PURPOSE: The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management is not standardized. We investigated rates of additional positive lymph nodes (LNs) at axillary lymph node dissection (ALND) and oncologic outcomes in patients with ypN0i+ treated with and without ALND. Methods: The Oncoplastic Breast Consortium-05/ICARO cohort study (ClinicalTrials.gov identifier: NCT06464341) retrospectively analyzed data from patients with stage I to III breast cancer with ITCs in SLNs after NAC from 62 centers in 18 countries. The primary end point was the 3-year rate of any axillary recurrence. The rate of any invasive recurrence was the secondary end point. Results: In total, 583 patients were included, of whom 182 (31%) had completion ALND and 401 (69%) did not. The median age was 48 years. Most patients (74%) were clinically node-positive at diagnosis and 41% had hormone receptor-positive/human epidermal growth factor receptor 2-negative tumors. The mean number of SLNs with ITCs was 1.2. Patients treated with ALND were more likely to present with cN2/3 disease (17% v 7%, P |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/39509672; info:eu-repo/semantics/altIdentifier/wos/WOS:001432096800009; volume:43; issue:7; firstpage:810; lastpage:820; numberofpages:11; journal:JOURNAL OF CLINICAL ONCOLOGY; https://hdl.handle.net/11577/3578765 |
| DOI: | 10.1200/jco.24.01052 |
| Availability: | https://hdl.handle.net/11577/3578765; https://doi.org/10.1200/jco.24.01052 |
| Accession Number: | edsbas.735997F |
| Database: | BASE |