Kidney Disease Management in the Hospital Setting: A Focus on Inappropriate Drug Prescriptions in Older Patients
| Title: | Kidney Disease Management in the Hospital Setting: A Focus on Inappropriate Drug Prescriptions in Older Patients |
|---|---|
| Authors: | Vincenzo Arcoraci; Maria Antonietta Barbieri; Michelangelo Rottura; Alessandro Nobili; Giuseppe Natoli; Christiano Argano; Giovanni Squadrito; Francesco Squadrito; Salvatore Corrao; on behalf of the REPOSI investigators |
| Source: | Frontiers in Pharmacology, Vol 12 (2021) |
| Publisher Information: | Frontiers Media S.A. |
| Publication Year: | 2021 |
| Collection: | Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: | chronic kidney disease; appropriateness of prescriptions; prescribing patterns; real-world data; hospital setting; older patients; Therapeutics. Pharmacology; RM1-950 |
| Description: | Aging with multimorbidity and polytherapy are the most significant factors that could led to inappropriate prescribing of contraindicated medications in patients with chronic kidney disease (CKD). The aim of this study was to evaluate the prescriptions of contraindicated drugs in older adults in CKD and to identify their associated factors in a hospital context. An observational retrospective study was carried out considering all patients ≥65 years with at least one serum creatinine value recorded into the REPOSI register into 2010–2016 period. The estimated glomerular filtration rate (eGFR) was applied to identify CKD. A descriptive analysis was performed to compare demographic and clinical characteristics; logistic regression models were used to estimate factors of inappropriate and percentage changes of drug use during hospitalization. A total of 4,713 hospitalized patients were recorded, of which 49.8% had an eGFR |
| Document Type: | article in journal/newspaper |
| Language: | English |
| Relation: | https://www.frontiersin.org/articles/10.3389/fphar.2021.749711/full; https://doaj.org/toc/1663-9812; https://doaj.org/article/4158358f819740ecb5e577447051cc30 |
| DOI: | 10.3389/fphar.2021.749711 |
| Availability: | https://doi.org/10.3389/fphar.2021.749711; https://doaj.org/article/4158358f819740ecb5e577447051cc30 |
| Accession Number: | edsbas.73A4E9F1 |
| Database: | BASE |