| Title: |
Pulmonary arterial hypertension in systemic lupus erythematosus: identification of risk factors and haemodynamics characteristics in a multicentre retrospective cohort |
| Authors: |
Emiliano Marasco; Christina Düsing; Stefanie Keymel; Alessandra Bortoluzzi; Claudia Bracaglia; Matthieu Canuet; Ilaria Cavazzana; Gamal Chehab; Veronica Codullo; Rebecca Fischer; Franco Franceschini; Micaela Fredi; Stefano Ghio; Lisa Keller; Alain Meyer; Carlomaurizio Montecucco; Jutta Richter; Marianne Riou Sezgin Sahin; Oliver Sander; Andreas Schwarting; Carlo Alberto Scirè; Ettore Silvagni; Konstantinos Triantafyllias; Giovanni Zanframundo; Lorenzo Cavagna; Matthias Schneider |
| Contributors: |
Marasco, Emiliano; Düsing, Christina; Keymel, Stefanie; Bortoluzzi, Alessandra; Bracaglia, Claudia; Canuet, Matthieu; Cavazzana, Ilaria; Chehab, Gamal; Codullo, Veronica; Fischer, Rebecca; Franceschini, Franco; Fredi, Micaela; Ghio, Stefano; Keller, Lisa; Meyer, Alain; Montecucco, Carlomaurizio; Richter, Jutta; Riou Sezgin Sahin, Marianne; Sander, Oliver; Schwarting, Andrea; Alberto Scirè, Carlo; Silvagni, Ettore; Triantafyllias, Konstantino; Zanframundo, Giovanni; Cavagna, Lorenzo; Schneider, Matthias |
| Publication Year: |
2025 |
| Collection: |
Università degli Studi di Ferrara: CINECA IRIS |
| Subject Terms: |
Lupus Erythematosus; Systemic; Pulmonary Arterial Hypertension; Risk Factors |
| Description: |
Objectives: The aim of our work was to identify specific patterns in clinical features and nailfold capillary changes that may help in screening for pulmonary arterial hypertension (PAH) in patients with systemic lupus erythematosus (SLE). Methods: We identified patients with SLE and type I PAH (n=20) without other connective tissue diseases and collected demographic, clinical and laboratory features. We selected as controls patients with SLE who underwent cardiopulmonary screening to exclude PAH (n=87): we collected demographic, clinical and laboratory features and performed nailfold videocapillaroscopy (NVC). Results: All patients with SLE-PAH were women; age and disease duration were not different from patients with SLE without PAH. Lupus anticoagulant (LAC)+and anti-ribonucleoprotein (RNP)+were more prevalent in patients with SLE-PAH (respectively, PAH 45.0% vs no-PAH 20.5%, p=0.042; PAH 45.0% vs no-PAH 19.5%, p=0.035). No differences were observed for anti-Sm, anti-Ro, anti-La and anti-cardiolipin and anti-beta2GPI antibodies. Among clinical features, mucocutaneous and central nervous system involvement were more prevalent in patients with SLE-PAH than in SLE controls (respectively, PAH 65.0% vs no-PAH 34.5%, p=0.024; PAH 25.0% vs no-PAH 8.0%, p=0.046). Raynaud's phenomenon (RP) was more prevalent in patients with SLE-PAH than in SLE controls (PAH 60.0% vs no-PAH 13.8%, p |
| Document Type: |
article in journal/newspaper |
| File Description: |
STAMPA |
| Language: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/40514051; info:eu-repo/semantics/altIdentifier/wos/WOS:001510015000001; volume:12; issue:1; firstpage:e001471-1; lastpage:e001471-10; numberofpages:10; journal:LUPUS SCIENCE & MEDICINE; https://hdl.handle.net/11392/2592196; https://lupus.bmj.com/content/12/1/e001471 |
| DOI: |
10.1136/lupus-2024-001471 |
| Availability: |
https://hdl.handle.net/11392/2592196; https://doi.org/10.1136/lupus-2024-001471; https://lupus.bmj.com/content/12/1/e001471 |
| Rights: |
info:eu-repo/semantics/openAccess ; license:Creative commons ; license uri:http://creativecommons.org/licenses/by-nc/4.0/ |
| Accession Number: |
edsbas.73BA5A2D |
| Database: |
BASE |