| Title: |
Long-term prognostic value of myocardial perfusion scintigraphy in patients with suspected coronary artery disease: systematic review and meta-analysis |
| Authors: |
Ihekwaba, U; Johnson, N; Choi, JS; Savarese, G; Orsini, N; Khoo, J; Squire, I; Kardos, A |
| Publisher Information: |
BMJ Publishing Group |
| Publication Year: |
2025 |
| Collection: |
Oxford University Research Archive (ORA) |
| Description: |
BackgroundLong-term outcome of contemporary myocardial perfusion scintigraphy (MPS) has not been assessed systematically.ObjectiveTo evaluate the association between results of MPS and long-term outcomes for patients with suspected coronary artery disease (CAD).MethodsElectronic databases were searched for Randomised controlled trials evaluating long-term outcome (≥12 months) of MPS in patients with suspected of CAD since year 2000. A meta-analysis adopting the random effects model was used to derive pooled estimates. The primary outcome was the composite of all-cause or cardiovascular mortality and non-fatal myocardial infarction as defined in individual trials, termed as major adverse cardiovascular event (MACE). Secondary outcome was all-cause or cardiovascular mortality. Positive MPS result was defined as reversible perfusion defect in any coronary artery territory.ResultsFour trials fulfilled the search criteria. A total of 1764 patient had MPS with a median follow-up of 35.7 months (range 17-57). The mean age was 59 years and 50% were male. Fifty-three per cent had hypertension, 43% had dyslipidaemia, 15% were current smokers and 61% had diabetes mellitus. The overall annual event rate was 1.42% for the composite MACE and 0.22% for all-cause or cardiovascular mortality. Compared with negative MPS results, positive MPS was associated with an increased risk of the composite MACE and all-cause or cardiovascular mortality with an annual event rate of 2.16% versus 0.66%, OR 2.71 (1.38, 5.32) and 0.34% versus 0.10%, OR 3.41 (1.44, 8.11), respectively.ConclusionIn this meta-analysis, reversible perfusion defect on MPS was associated with higher risk of composite MACE, and that of all-cause or cardiovascular mortality. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1136/openhrt-2025-003521 |
| Availability: |
https://doi.org/10.1136/openhrt-2025-003521; https://ora.ox.ac.uk/objects/uuid:bd25dd22-6915-45ca-88de-822848372f2d |
| Rights: |
info:eu-repo/semantics/openAccess ; CC Attribution-NonCommercial (CC BY-NC) |
| Accession Number: |
edsbas.74191033 |
| Database: |
BASE |