| Title: |
P0656 Low colorectal cancer incidence and a signal of inflammation-associated risk in a modern multicentre IBD–PSC cohort: a TAILOR-IBD study |
| Authors: |
Radia, C; Nishad, N; Porter, R; Peggie, E; Colwill, M; Patel, C; Yeo, J H; Harrow, P; Patel, K V; Samaan, M; Mawdsley, J; Johnston, M P; Seenan, J P; Subramanian, S; Gordon, H; Culver, E; Pavlidis, P; Kent, A |
| Source: |
Journal of Crohn’s and Colitis ; volume 20, issue Supplement_1 ; ISSN 1873-9946 1876-4479 |
| Publisher Information: |
Oxford University Press (OUP) |
| Publication Year: |
2026 |
| Description: |
Background Primary sclerosing cholangitis with co-existent inflammatory bowel disease (IBD-PSC) confers elevated colorectal cancer (CRC) risk, but modern cohort-level incidence data reflecting changing practice remain limited. We examined CRC occurrence and associations with clinical factors in a large multicentre UK IBD-PSC cohort. Methods We analysed 472 patients with IBD-PSC from 7 UK centres with IBD diagnosed in 2000 or later. Demographic, clinical, and treatment data were extracted. Follow-up was defined as time from IBD diagnosis to the earliest of CRC, colectomy, or last follow-up. We report descriptive statistics, univariate logistic regressions, and CRC-free survival. Small event numbers precluded multivariable modelling. Results Among 472 PSC-IBD patients 65% were male, and 367 (78%) UC, 81 (17%) CD, 24 (5%) IBD-u. Most had large-duct PSC (83%) and extensive colitis (E3, 68%). Total follow-up summed 5176 patient-years, median 11 years (IQR 6–16) per patient. Median age at IBD diagnosis was 23 years (15–35). Ten patients developed CRC (2%), an incidence of 1.93 per 1000 patient-years. Among CRC cases median age at IBD diagnosis was 24 years (20–40), time from IBD diagnosis to CRC was 9 years (8–12), and age at CRC was 35 years (33–45). Those with CRC were older at PSC diagnosis with an age of 36 (30-45) compared to those without CRC (25, 16-40) though not significantly (p = 0.094). There was a trend towards higher advanced therapy use in CRC cases with 1.5 per patient (0.25–2) and 70% receiving at least one, compared to non-CRC cases with 0 (IQR 0–2) and 45% (p = 0.116). Of the 10 CRCs: 9/10 were right sided (one had synchronous sigmoid CRC) and 1 had unknown site; 9/10 were found in actively inflamed segments, 3 of which were found incidentally following colectomy for refractory disease. Endoscopic activity at prior colonoscopy (median interval 2 years): 7/10 moderate-severe activity, 1/10 quiescent disease, 1/10 no colonoscopy for >8 years, 1/10 unknown. Univariate logistic ... |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| DOI: |
10.1093/ecco-jcc/jjaf231.837 |
| Availability: |
https://doi.org/10.1093/ecco-jcc/jjaf231.837; https://academic.oup.com/ecco-jcc/article-pdf/20/Supplement_1/jjaf231.837/66493904/jjaf231.837.pdf |
| Rights: |
https://academic.oup.com/pages/standard-publication-reuse-rights |
| Accession Number: |
edsbas.745D3417 |
| Database: |
BASE |