Additional file 2 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma
| Title: | Additional file 2 of Identifying and exploiting combinatorial synthetic lethality by characterizing adaptive kinome rewiring of EGFRvIII-driven glioblastoma |
|---|---|
| Authors: | Benjamin Lin; Abigail K. Shelton; Erin Smithberger; Julia Ziebro; Kasey R. Skinner; Ryan E. Bash; Richard Kirkman; Allie Stamper; Madison Butler; Alex Flores; Steven P. Angus; Michael P. East; Timothy F. Cloughesy; David A. Nathanson; Michael E. Berens; Jann N. Sarkaria; Zev A. Binder; Donald M. O’Rourke; Timothy C. Howton; Brittany N. Lasseigne; Christopher D. Willey; Gary L. Johnson; Anita B. Hjelmeland; Frank B. Furnari; C. Ryan Miller |
| Publication Year: | 2025 |
| Collection: | The University of Auckland: Figshare |
| Subject Terms: | Biochemistry; Medicine; Genetics; Pharmacology; Biotechnology; Marine Biology; Cancer; Hematology; Virology; Computational Biology; Biological Sciences not elsewhere classified; Chemical Sciences not elsewhere classified; EGFR; Glioblastoma; Synthetic lethality; Kinome rewiring; Upfront combinatorial therapy |
| Description: | Supplementary Material 2: Fig. S1 Model generation. Cdkn2a−/− mouse astrocytes were cultured and transduced with retrovirus encoding human EGFRvIII as described (A) [4, 40]. Resistant models (B) were generated in vitro via dose escalation of EGFR TKI (gefitinib or erlotinib) as described [51]. Figure created with BioRender |
| Document Type: | still image |
| Language: | unknown |
| DOI: | 10.6084/m9.figshare.29431966.v1 |
| Availability: | https://doi.org/10.6084/m9.figshare.29431966.v1; https://figshare.com/articles/figure/Additional_file_2_of_Identifying_and_exploiting_combinatorial_synthetic_lethality_by_characterizing_adaptive_kinome_rewiring_of_EGFRvIII-driven_glioblastoma/29431966 |
| Rights: | CC BY |
| Accession Number: | edsbas.74765476 |
| Database: | BASE |