| Title: |
A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes |
| Authors: |
Xudong Han; Yichi Zhang; Jillian N. Petrosky; Sarah Bald; Richard M. Sherva; Adam Labadorf; Jonathan D. Cherry; Jaeyoon Chung; Kurt Farrell; Bobak Abdolmohammadi; Shruti Durape; Brett M. Martin; Joseph N. Palmisano; John J. Farrell; Victor E. Alvarez; Bertrand R. Huber; Brigid Dwyer; Daniel H. Daneshvar; Kristen Dams-O’Connor; Gyungah R. Jun; Kathryn L. Lunetta; Lee E. Goldstein; Douglas I. Katz; Robert C. Cantu; Martha E. Shenton; Jeffrey L. Cummings; Eric M. Reiman; Robert A. Stern; Michael L. Alosco; Yorghos Tripodis; Lindsay A. Farrer; Thor D. Stein; John F. Crary; Ann C. McKee; Jesse Mez |
| Source: |
Cell Reports Medicine, Vol 6, Iss 5, Pp 102084- (2025) |
| Publisher Information: |
Elsevier |
| Publication Year: |
2025 |
| Collection: |
Directory of Open Access Journals: DOAJ Articles |
| Subject Terms: |
chronic traumatic encephalopathy; MAPT; 17q21.31; repetitive head impacts; traumatic brain injury; structural haplotypes; Medicine (General); R5-920 |
| Description: |
Summary: Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impact (RHI) exposure. Genetic variation in the 17q21.31 region, containing microtubule-associated protein tau (MAPT), has been implicated in tauopathies but has not been investigated in CTE. The region includes a megabase-long inversion (H1/H2) and copy-number variations, including α, β, and γ segments, which can be characterized as nine segregating structural haplotypes. We leveraged array SNP data and a reference panel across the 17q21.31 region to impute structural haplotypes and test their association with CTE endophenotypes in 447 European ancestry brain donors with RHI exposure. The H1β1γ1 haplotype was significantly associated with dementia and semi-quantitative tau burden in multiple cortical and medial temporal regions commonly affected in CTE. H1β1γ1 differential expression analyses in dorsolateral frontal cortex implicated cis-acting genes and inflammatory pathways. Taken together, the H1β1γ1 haplotype may help explain CTE heterogeneity among those with similar RHI exposure. |
| Document Type: |
article in journal/newspaper |
| Language: |
English |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2666379125001570; https://doaj.org/toc/2666-3791; https://doaj.org/article/878e0612b01541218407d65e2beaae56 |
| DOI: |
10.1016/j.xcrm.2025.102084 |
| Availability: |
https://doi.org/10.1016/j.xcrm.2025.102084; https://doaj.org/article/878e0612b01541218407d65e2beaae56 |
| Accession Number: |
edsbas.74997B9C |
| Database: |
BASE |