| Title: |
The role of IL-22 in viral infections: paradigms and paradoxes |
| Authors: |
Gimeno Brias, Silvia; Stack, Gabrielle; Stacey, Maria A.; Redwood, Alec J.; Humphreys, Ian R. |
| Publisher Information: |
Frontiers Research Foundation |
| Publication Year: |
2016 |
| Collection: |
Cardiff University: ORCA (Online Research @ Cardiff) |
| Subject Terms: |
QR180 Immunology |
| Description: |
Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines. Hematopoietic cells express IL-22, and this cytokine signals through the heterodimeric IL-22 receptor expressed by non-hematopoietic cells. A growing body of evidence points toward a role for IL-22 in a diverse array of biological functions ranging from cellular proliferation, tissue protection and regeneration, and inflammation. In recent years, the role that IL-22 plays in antiviral immune responses has been examined in a number of infection models. Herein, we assess our current understanding of how IL-22 determines the outcome of viral infections and define common mechanisms that are evident from, sometimes paradoxical, findings derived from these studies. Finally, we discuss the potential therapeutic utility of IL-22 manipulation in the treatment and prevention of viral infections and associated pathologies. |
| Document Type: |
article in journal/newspaper |
| File Description: |
application/pdf |
| Language: |
English |
| Relation: |
https://orca.cardiff.ac.uk/id/eprint/92017/1/fimmu-07-00211.pdf; Gimeno Brias, Silvia, Stack, Gabrielle, Stacey, Maria A., Redwood, Alec J. and Humphreys, Ian R. https://orca.cardiff.ac.uk/view/cardiffauthors/A1077626.html orcid:0000-0002-9512-5337 orcid:0000-0002-9512-5337 2016. The role of IL-22 in viral infections: paradigms and paradoxes. Frontiers in Immunology 7 , 00211. 10.3389/fimmu.2016.00211 https://doi.org/10.3389/fimmu.2016.00211 file https://orca.cardiff.ac.uk/id/eprint/92017/1/fimmu-07-00211.pdf |
| DOI: |
10.3389/fimmu.2016.00211 |
| Availability: |
https://orca.cardiff.ac.uk/id/eprint/92017/; https://doi.org/10.3389/fimmu.2016.00211 |
| Rights: |
cc_by |
| Accession Number: |
edsbas.751C4A42 |
| Database: |
BASE |