Sequence determinants of protein phase separation and recognition by protein phase-separated condensates through molecular dynamics and active learning
| Title: | Sequence determinants of protein phase separation and recognition by protein phase-separated condensates through molecular dynamics and active learning |
|---|---|
| Authors: | Changiarath, Arya; Arya, Aayush; Xenidis, Vasileios A.; Padeken, Jan; Stelzl, Lukas S. |
| Contributors: | Deutsche Forschungsgemeinschaft |
| Source: | Faraday Discussions ; volume 256, page 235-254 ; ISSN 1359-6640 1364-5498 |
| Publisher Information: | Royal Society of Chemistry (RSC) |
| Publication Year: | 2025 |
| Description: | We investigate three related questions: can we identify the sequence determinants which lead to protein self interactions and phase separation; can we understand and design new sequences which selectively bind to protein condensates?; can we design multiphasic condensates? |
| Document Type: | article in journal/newspaper |
| Language: | English |
| DOI: | 10.1039/d4fd00099d |
| Availability: | https://doi.org/10.1039/d4fd00099d; http://pubs.rsc.org/en/content/articlepdf/2025/FD/D4FD00099D |
| Rights: | http://creativecommons.org/licenses/by/3.0/ |
| Accession Number: | edsbas.75551E65 |
| Database: | BASE |